Process Instruments and Controls Handbook

Considine, Douglas M.; Edmonds, Sylvan M.

doi:10.1149/1.2427253

Cited by 25 publications

(41 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The proportional feedback term should correct for any potential inaccuracies contained in F 0 . On the other hand, the classical shortcoming of proportional-only control is that, except in presence of a pure capacity process, its use invariably leads to a non-zero steady-state offset [23]. A simple way of compensating for this effect is to add an integral term which enables the removal of the residual steady-state error.…”

Section: Controller Designmentioning

confidence: 99%

Simple control of specific growth rate in biotechnological fed-batch processes based on enhanced online measurements of biomass

Dabros

Schuler

Marison

2010

Bioprocess Biosyst Eng

View full text Add to dashboard Cite

Reliable control of the specific growth rate (μ) in fed-batch fermentations depends on the availability of accurate online estimations of the controlled variable. Due to difficulties in measuring biomass, μ is typically estimated using reference models relating measurements of substrate consumption or oxygen uptake rate to biomass growth. However, as culture conditions vary, these models are adapted dynamically, resulting in complex algorithms that lack the necessary robustness for industrial applicability. A simpler approach is presented where biomass is monitored using dielectric spectroscopy. The measurements are subjected to online balances and reconciled in real time against metabolite concentrations and off-gas composition. The reconciled biomass values serve to estimate the growth rate and a simple control scheme is implemented to maintain the desired value of μ. The methodology is developed with the yeast Kluyveromyces marxianus, tested for disturbance rejection and validated with two other strains. It is applicable to other cellular systems with minor modifications.

show abstract

Section: Controller Designmentioning

confidence: 99%

Simple control of specific growth rate in biotechnological fed-batch processes based on enhanced online measurements of biomass

Dabros

Schuler

Marison

2010

Bioprocess Biosyst Eng

View full text Add to dashboard Cite

show abstract

“…in the works [10][11][12][13][14] and recently in [15,16]. Four-electrode conductivity sensors developed by Considine and Considine [17] and by Nasr-El-Din et al [18] were used e.g. in their works [19,20].…”

Section: Introductionmentioning

confidence: 99%

Solid particle distribution of moderately concentrated suspensions in a pilot plant stirred vessel

Špidla

Sinevič

Jahoda

et al. 2005

Chemical Engineering Journal

View full text Add to dashboard Cite

“…Thermistor resistance (R TH ) and temperature (T) in Kelvin were modeled using the empirical equation developed by Considine [4]:…”

Section: Relationship Between Resistance and Temperaturementioning

confidence: 99%

Geometry and reactor synthesis: maximizing conversion of the ethyl acetate process

2015

View full text Add to dashboard Cite

This paper describes how experimentally generated results were used to optimize conversion of a process using adiabatic batch reactor systems. The process used in the experiment was exothermic reversible process. The experiments were conducted using Dewar Thermosflask operating under adiabatic conditions. Equilibrium conversions were determined from temperature-time information. Temperatures were determined using negative temperature coefficient thermistor. For a single batch process, the equilibrium conversion determined experimentally was shown to be 0.55 and 0.21 with respect to acetic acid using two initial temperatures of 283 K and 295 K, respectively. It is shown by a simple geometrical approach that without the knowledge of the kinetics of the process, by increasing the number of reactors and considering internal cooling systems, the reaction equilibrium lines were crossed and conversion improved significantly. The paper also shows that one can attain the maximum possible conversion of 0.72, thus increasing equilibrium conversions by 31 % by adding a single adiabatic reactor to the single-stage adiabatic reactor by this geometrical technique, and hence proposes the optimal reactor configuration with interstage cooling system to achieve this optimal conversion.

show abstract

Process Instruments and Controls Handbook

Abstract: not Available.

Cited by 25 publications

References 0 publications

Simple control of specific growth rate in biotechnological fed-batch processes based on enhanced online measurements of biomass

Simple control of specific growth rate in biotechnological fed-batch processes based on enhanced online measurements of biomass

Solid particle distribution of moderately concentrated suspensions in a pilot plant stirred vessel

Geometry and reactor synthesis: maximizing conversion of the ethyl acetate process

Contact Info

Product

Resources

About