Process intensification using a spiral capillary microreactor for continuous flow synthesis of performic acid and it’s kinetic study

Maralla, Yadagiri; Sonawane, Shirish H.

doi:10.1016/j.cep.2018.01.009

Cited by 19 publications

(17 citation statements)

References 32 publications

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“…The microreactor technology has recently proved to be a very promising alternative , , to follow the kinetics of organic reactions , , , .…”

Section: Resultsmentioning

confidence: 99%

“…Accordingly, the reaction conditions are uniform, and all molecules pass with the same mean residence time and temperature . Owing to the high surface/volume ratio, MRT offers several advantages over the batch process, including (a) easier temperature and pressure control, (b) more efficient diffusion of molecules, (c) higher reaction rate, (d) higher conversion and selectivity, (e) safer operation, (f) less waste generation, (g) higher product purity, and (h) better reliability and reproducibility , , . Thus, MRT has gained attention from academics as well as the chemical and pharmaceutical industries, and research in this area has been increasing exponentially , , , .…”

Section: Introductionmentioning

confidence: 99%

“…Owing to the high surface/volume ratio, MRT offers several advantages over the batch process, including (a) easier temperature and pressure control, (b) more efficient diffusion of molecules, (c) higher reaction rate, (d) higher conversion and selectivity, (e) safer operation, (f) less waste generation, (g) higher product purity, and (h) better reliability and reproducibility , , . Thus, MRT has gained attention from academics as well as the chemical and pharmaceutical industries, and research in this area has been increasing exponentially , , , . Our proposal is to replace the current scale‐up in drug development with the numbering‐up approach, i.e., increasing the number of microreactors in parallel and then reducing the time required for compounds to reach the production line , .…”

Section: Introductionmentioning

confidence: 99%

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Microreactor Technology as a Tool for the Synthesis of a Glitazone Drug Intermediate

et al. 2018

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One of the bottlenecks in the pharmaceutical industry is drug production scaleup, which can be performed by microreactor technology. Such an approach was applied to the synthesis of (Z)-5-(4-hydroxybenzylidene)thiazolidine-2,4-dione, a bioactive aromatic heterocyclic compound belonging to the class of glitazones. n-Propanol was the best solvent and piperidine the best catalyst for the batch reaction, which was completed in only 5.5 h. In the microreactor, the productivity was almost independent of solvent. The microreactor behaved as a plug-flow reactor and operated at a steady state for ten hours without efficiency loss. The results suggest that microreactors may replace batch reactors in scaling up drug production.

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“…The microreactor technology has recently proved to be a very promising alternative , , to follow the kinetics of organic reactions , , , .…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Microreactor Technology as a Tool for the Synthesis of a Glitazone Drug Intermediate

et al. 2018

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“…The liquid phase of the sample (product) was analyzed off -line by titration procedures of Greenspan and Mackellar method [6,8,10,[21][22][23]. The concentration of HP was determined by titration against a prepared standard solution of ACS and the concentration of PPA was determined by titration against a prepared standard solution of sodium thiosulphate.…”

Section: Analysis Methodsmentioning

confidence: 99%

“…So, in order to synthesize PPA, a catalyst is required, which may be a homogeneous catalyst such as mineral acids like sulfuric acid, phosphoric acid etc. [6,9,10] or heterogeneous catalyst such as Amberlite IR-120, Amberlyst 15, Smopex-101, Dowex etc. [8].…”

Section: Introductionmentioning

confidence: 99%

Process Intensification by Using a Helical Capillary Microreactor for a Continuous Flow Synthesis of Peroxypropionic Acid and Its Kinetic Study

Maralla

Sonawane

2019

Period. Polytech. Chem. Eng.

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Peroxypropionic acid (PPA) is an important organic chemical compound. Due to its versatile oxidizing properties, it is used in the oil, chemical and other industries. In this article, an attempt was made for the production of PPA in a Teflon helical capillary microreactor without and with homogeneous catalyst. The article reports the perhydrolysis of PPA with the effect of various parameters such as concentration of hydrogen peroxide, molar ratio of reactants, radius of curvature of the microreactor, concentration of catalyst and temperature. The reaction is slow, as the PPA equilibrium was found to be reached within 10 min at a temperature of 50 °C and at 10 mol % catalyst loading based on propionic acid. The reaction was carried out in 13.25 and 23.25 mm radius of curvature of the microreactor in which 4.0375 and 3.488 mol/L concentrations of PPA respectively were obtained at 50 ºC and 10 mol % catalyst. It indicates that as radius of curvature decreases, better mixing was provided among the reactants for the reaction to give enhanced yield and selectivity. From the experimental data and the kinetic expressions, the expressions of activation energies and reaction rate constants were determined. For PPA synthesis and hydrolysis, the activation energies were 43.897 and 20.658 kJ/mol respectively without catalyst, while the activation energies for both the cases were 42.314 and 17.514 kJ/mol respectively with catalyst of 10 mol% based on propionic acid. The dean number, curve tube friction factor and pressure drop also determined for the helical capillary microreactor.

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Recent Progress in Intensifying Synthesis of Acrylic Microspheres for Catalysis

Gaddale

Kale

Srinivasan

et al. 2023

Adv Materials Inter

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Over the past decades, there has been an escalating rise in the need for chemicals and catalytic materials to keep up with global demands. Addressing those issues by conventional methods often becomes inefficient, with myriad operational risks. Process intensification methods through procedural and equipment‐based modifications have been considered greener, have higher heat and mass transfer rates, and operate with lower costs. In this review, research using ultrasonic reactors and microreactors, along with developments through an integrated external energy source, for synthesizing acrylic microspheres is covered extensively. Acrylic microspheres have garnered much interest for their biocompatibility, affinity toward functionalization, and wide range of applications. Core–shell, composite, functional‐group modified, and porous acrylic microspheres are used for enzyme immobilization and as catalyst carriers. The use of acrylic support has provided huge improvements in catalytic activity, reusability, recyclability, and overall stability. Finally, various other process intensification methods and alternate support materials are covered to help enhance future developments in the field of catalysis.

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Process intensification using a spiral capillary microreactor for continuous flow synthesis of performic acid and it’s kinetic study

Cited by 19 publications

References 32 publications

Microreactor Technology as a Tool for the Synthesis of a Glitazone Drug Intermediate

Microreactor Technology as a Tool for the Synthesis of a Glitazone Drug Intermediate

Process Intensification by Using a Helical Capillary Microreactor for a Continuous Flow Synthesis of Peroxypropionic Acid and Its Kinetic Study

Recent Progress in Intensifying Synthesis of Acrylic Microspheres for Catalysis

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