Process optimization and evaluation of novel baicalin solid nanocrystals

Bark extract mediated green synthesis of silver nanoparticles: Evaluation of antimicrobial activity and antiproliferative response against osteosarcoma

“…10 dispersion in the absence of steric stabilization [37]. X-ray powder diffraction (XRD) technique was used to identify the crystalline phase, orientation and grain size of the synthesized nanoparticles.…”

Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies

“…Baicalein nanocrystal [27], baicalein-hydroxypropyl-β-cyclodextrin inclusion complex [28], baicalein self-microemulsifying drug delivery system [29], and baicalein solid dispersion [30]have been developed to improve dissolution and oral bioavailability of baicalein. Some nano-based formulations such as solid nanocrystals [31], nanoemulsions [32], and solid lipid nanoparticles [33]have been designed for increasing baicalin's solubility and absorption rate and improving its oral bioavailability. Besides, change administration route of baicalein may be employed to avoid the first-pass effect of the gastrointestinal tract or liver and enhance its bioavailability.…”

Preparation, optimization, characterization and cytotoxicity in vitro of Baicalin-loaded mixed micelles

“…Based on the optimization and further screening experiments, the final formulation was as follows, X 1 = 100 mg, X 2 = 100 mg, X 3 = 45 mg, X 4 = 4 mL. The solubility of BC in the developed mixed micelle system was increased to 10.20 mg/mL, which was notably higher than that of coarse BC in water (53.51 lg/mL) [13]. The high DL and EE were attributed to the hydrophobic interaction of lipophilic drugs and hydrophobic core of micelles [29].…”

“…In spite of plenty of superiorities, the low water-solubility of BC brought many defects such as weak stability in solution, poor absorption and low bioavailability [2,7]. A series of BC-loaded formulations have been developed including gelling system [8], solid lipid nanoparticles [9], phospholipid complex [10], coprecipitate [11], nanoemulsion [12], and solid nanocrystals [13]. Up to now, no micelle formulation has been reported for improving the solubility and enhancing treatment effect of BC.…”