Process optimization and modelling of sphalerite flotation from a low-grade Zn-Pb ore using response surface methodology

Mehrabani, Javad Vazifeh; Noaparast, Mohammad; Mousavi, Seyyed Mohammad; Dehghan, R.; Ghorbani, Ali

doi:10.1016/j.seppur.2010.02.005

Cited by 79 publications

(36 citation statements)

References 10 publications

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“…36 CCD is an effective alternative to full factorial design and enables the gathering of more data with a lower number of experiments. 37 Ps, ZP, and morphology of PUe-scU clNs Appropriate PS and a narrow size range in the ophthalmic formulation can ensure low irritation, sufficient bioavailability, and good compatibility in ocular tissues.…”

Section: Results and Discussion Central Ccdmentioning

confidence: 99%

Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies

Wang¹,

Zhao²,

Li³

et al. 2017

IJN

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The purpose of this study was to prepare, optimize, and characterize a cationic lipid nanoparticle (CLN) system containing multicomponent drugs using a molecular dynamics model as a novel method of evaluating formulations. Puerarin (PUE) and scutellarin (SCU) were used as model drugs. CLNs were successfully prepared using melt-emulsion ultrasonication and low temperature-solidification technique. The properties of CLNs such as morphology, particle size, zeta potential, entrapment efficiency (EE), drug loading (DL), and drug release behavior were investigated. The CLNs were evaluated by corneal permeation, preocular retention time, and pharmacokinetics in the aqueous humor. Additionally, a molecular dynamics model was used to evaluate the formulation. Electron microscopy results showed that the nanoparticles were approximately spherical in shape. The EE (%) and DL (%) values of PUE and SCU in the optimal formulation were 56.60±3.73, 72.31±1.96 and 1.68±0.17, 2.44±1.14, respectively. The pharmacokinetic study in the aqueous humor showed that compared with the PUE and SCU solution, the area under the concentration–time curve (AUC) value of PUE was enhanced by 2.33-fold for PUE-SCU CLNs ( p <0.01), and the SCU AUC was enhanced by 2.32-fold ( p <0.01). In the molecular dynamics model, PUE and SCU passed through the POPC bilayer, with an obvious difference in the free energy well depth. It was found that the maximum free energy required for PUE and SCU transmembrane movement was ~15 and 88 kJ·mol −1 , respectively. These findings indicated that compared with SCU, PUE easily passed through the membrane. The diffusion coefficient for PUE and SCU were 4.1×10 −3 ±0.0027 and 1.0×10 −3 ±0.0006 e −5 cm 2 ·s −1 , respectively. Data from the molecular dynamics model were consistent with the experimental data. All data indicated that CLNs have a great potential for ocular administration and can be used as an ocular delivery system for multicomponent drugs. Moreover, the molecular dynamics model can also be used as a novel method for evaluating formulations.

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Section: Results and Discussion Central Ccdmentioning

confidence: 99%

Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies

Wang¹,

Zhao²,

Li³

et al. 2017

IJN

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show abstract

“…Using a response surface methodology (RSM) to design the experiments, the optimum flotation parameters can be obtained by the minimum number of experiments compared with the traditional factorial experiments, which demanded an investigation of all the possible combinations [22,23]. In the direct flotation process of the phosphate ore, especially the fine-particle sized one, a high pulp temperature was required to improve the solubility and activation energy of the reagents.…”

Section: Response Surface Methodology Analysismentioning

confidence: 99%

Ambient Temperature Flotation of Sedimentary Phosphate Ore Using Cottonseed Oil as a Collector

et al. 2017

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Abstract:The mid-low grade sedimentary phosphate ore, abundant in silicate and carbonate gangue minerals, exhibits a poor processability. It is conventionally enriched using high temperature flotation to remove silicate gangues with fatty acid as a collector. Cottonseed oil has been proved to be an efficient collector for achieving ambient temperature flotation of the sedimentary phosphate ore used in this study. Flotation kinetics was investigated to ascertain the excellent collecting performance of cottonseed oil, as compared with oleic acid, and the phosphate flotation fitted well with the first-order flotation model. Based on the analysis of flotation reagent effect on the direct flotation process using the response surface methodology (RSM), a closed circuit of direct-reverse flotation for stepwise removing silicate and carbonate gangues from the sedimentary phosphate ore was established. Consequently, a required high quality of phosphate concentrate containing 30.16% P 2 O 5 was obtained, with a recovery of 90.90%. Scanning electron microscopy (SEM) and X-ray diffraction analysis (XRD) of the flotation products confirmed that the majority of silicate and carbonate gangues were effectively removed from the concentrate products.

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“…This statistical approach is a suitable technique for multi-factor experiments and has the advantage of identifying the most favorable conditions of the processes by determining the common relationship between various factors. Central composite design (CCD), which is a popular response surface method for the experimental design, was employed to optimize the amount of conversion yield (Mehrabani et al, 2010). The objective of employing CCD was to optimize the effects of the variables to get the best response.…”

Section: Rsmmentioning

confidence: 99%

Methane decomposition for carbon nanotube production: Optimization of the reaction parameters using response surface methodology

Allaedini

Aminayi

Tasirin

2016

Chemical Engineering Research and Design

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Process optimization and modelling of sphalerite flotation from a low-grade Zn-Pb ore using response surface methodology

Cited by 79 publications

References 10 publications

Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies

Novel cationic lipid nanoparticles as an ophthalmic delivery system for multicomponent drugs: development, characterization, in vitro permeation, in vivo pharmacokinetic, and molecular dynamics studies

Ambient Temperature Flotation of Sedimentary Phosphate Ore Using Cottonseed Oil as a Collector

Methane decomposition for carbon nanotube production: Optimization of the reaction parameters using response surface methodology

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