Process optimization for clean manufacturing: Supercritical fluid extraction for B-carotene production

Kalampoukas, G.; Dervakos, G.A.

doi:10.1016/0098-1354(96)00237-2

Cited by 6 publications

(5 citation statements)

References 4 publications

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“…Many drawbacks in traditional extraction techniques such as low efficiency, pollution, and organic solvent residues hindered the further application of natural active ingredient. − Supercritical fluid extraction attracted a lot of attention, but the high demands of pressure, energy, and investment impeded its large-scale application. , Later, the subcritical CO 2 extraction (SCCE) technique emerged, which is beneficial to the environment and satisfies today’s pursuit for “green” processing . As a modified method of the supercritical CO 2 extraction (SCE) technique, SCCE requires lower temperature and pressure, with higher density and extraction power.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Enhanced Subcritical CO₂ Extraction of Lutein from Chlorella pyrenoidosa

Fan

Hou

Huang

et al. 2015

J. Agric. Food Chem.

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Lutein is an important pigment of Chlorella pyrenoidosa with many beneficial functions in human health. The main purpose of this study was to extract lutein from C. pyrenoidosa using ultrasound-enhanced subcritical CO2 extraction (USCCE). Effects of operating conditions on the extraction, including extraction pretreatment, temperature, pressure, time, CO2 flow rate, and ultrasonic power, were investigated, and an orthogonal experiment was designed to study the effects of extraction pressure, temperature, cosolvent amount, and time on the extraction yields. The USCCE method was compared with other extraction methods in terms of the yields of lutein and the microstructure of C. pyrenoidosa powder by scanning electron microscopy. A maximal extraction yield of 124.01 mg lutein/100 g crude material was achieved under optimal conditions of extraction temperature at 27 °C, extraction pressure at 21 MPa, cosolvent amount at 1.5 mL/g ethanol, and ultrasound power at 1000 W. Compared to other methods, USCCE could significantly increase the lutein extraction yield at lower extraction temperature and pressure. Furthermore, the kinetic models of USCCE and subcritical CO2 extraction (SCCE) of lutein from C. pyrenoidosa were set as E = 130.64 × (1 - e(-0.6599t)) and E = 101.82 × (1 - e(-0.5683t)), respectively. The differences of parameters in the kinetic models indicate that ultrasound was able to enhance the extraction process of SCCE.

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Section: Introductionmentioning

confidence: 99%

Ultrasound-Enhanced Subcritical CO₂ Extraction of Lutein from Chlorella pyrenoidosa

Fan

Hou

Huang

et al. 2015

J. Agric. Food Chem.

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“…Because the HiPco process is significantly less costly ($450/g vs. $1,830/g and $1,586/g for arc ablation and CVD, respectively) [16], we focused on the HiPco manufacturing method in the CCNLP model to explore profits under various EHS standards (High, Medium, Low). In the HiPco process, it is proposed that iron clusters form first, then solid carbon nucleates and grows SWNTs.…”

Section: Methodsmentioning

confidence: 99%

“…So far, relatively few publications have directly approached modelling MNMs occupational exposure risks, which include Monte Carlo models that compare various levels of environmental health and safety (EHS) standards for single wall carbon nanotube (SWCNT) manufacturing [15], and expert opinions on development of exposure-response functions for nanomaterials [16]. To minimize the risks of MNMs to workers’ health as well as to maximize their economic benefits, optimization models are efficient tools to manage MNMs manufacturing processes and reduce occupational exposure.…”

Section: Introductionmentioning

confidence: 99%

“…Previously, nonlinear programming (NLP) has been widely employed in technological optimization of manufacturing processes, such as agriculture [16], electronics industry [19,20], and construction [21]. NLP is one of the most frequently applied operational algorithms for real world problems as its fundamental theories have been well studied and as a result, a wide spectrum of user-friendly solution software with powerful computational capabilities have been developed.…”

Section: Introductionmentioning

confidence: 99%

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Management of Occupational Exposure to Engineered Nanoparticles Through a Chance-Constrained Nonlinear Programming Approach

Zhi

Yuan

Zhang

et al. 2013

IJERPH

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Critical environmental and human health concerns are associated with the rapidly growing fields of nanotechnology and manufactured nanomaterials (MNMs). The main risk arises from occupational exposure via chronic inhalation of nanoparticles. This research presents a chance-constrained nonlinear programming (CCNLP) optimization approach, which is developed to maximize the nanaomaterial production and minimize the risks of workplace exposure to MNMs. The CCNLP method integrates nonlinear programming (NLP) and chance-constrained programming (CCP), and handles uncertainties associated with both the nanomaterial production and workplace exposure control. The CCNLP method was examined through a single-walled carbon nanotube (SWNT) manufacturing process. The study results provide optimal production strategies and alternatives. It reveal that a high control measure guarantees that environmental health and safety (EHS) standards regulations are met, while a lower control level leads to increased risk of violating EHS regulations. The CCNLP optimization approach is a decision support tool for the optimization of the increasing MNMS manufacturing with workplace safety constraints under uncertainties.

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“…Several papers were published on the use of SC CO 2 to extract β-carotene from vegetables (13)(14)(15)(16)(17)(18), while some works deal with the SC extraction from R. canina L. (19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

Supercritical Extraction of Carotenoids from Rosa canina L. Hips and their Formulation with β-Cyclodextrin

et al. 2008

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Abstract. The purpose of this research was to preliminary assess the suitability of a new method for the preparation of a solid formulation in form of powder composed by β-cyclodextrin and the supercritical extract of Rosa canina hips. The method implies the extraction of carotenoids, in particular β-carotene, from freeze dried fruits of R. canina with supercritical CO 2 at 70°C and 300 bar, in the presence of varying quantity of ethanol as entrainer. The obtained supercritical solution is then expanded at ambient conditions into an aqueous solution of β-cyclodextrin to favour the interaction between β-cyclodextrin and the lipophilic components of the extract. β-carotene solubility (mole fraction) in supercritical CO 2 or in supercritical CO 2 /ethanol mixtures were in the order of 1 10 −7 . The β-carotene extracted from R.canina fruits (nearly 10 μg/g of dry matrix), interacts almost quantitatively with β-cyclodextrin affording a solid phase, which presents a low apparent solubility in water. Finally the interaction with β-cyclodextrin results in a higher concentration of the β-carotene trans-form relative to the cis-form in the extracted product when collected in an aqueous solution of β-cyclodextrin with respect to the extract in n-hexane.

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Process optimization for clean manufacturing: Supercritical fluid extraction for B-carotene production

Cited by 6 publications

References 4 publications

Ultrasound-Enhanced Subcritical CO₂ Extraction of Lutein from Chlorella pyrenoidosa

Ultrasound-Enhanced Subcritical CO₂ Extraction of Lutein from Chlorella pyrenoidosa

Management of Occupational Exposure to Engineered Nanoparticles Through a Chance-Constrained Nonlinear Programming Approach

Supercritical Extraction of Carotenoids from Rosa canina L. Hips and their Formulation with β-Cyclodextrin

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Process optimization for clean manufacturing: Supercritical fluid extraction for B-carotene production

Cited by 6 publications

References 4 publications

Ultrasound-Enhanced Subcritical CO2 Extraction of Lutein from Chlorella pyrenoidosa

Ultrasound-Enhanced Subcritical CO2 Extraction of Lutein from Chlorella pyrenoidosa

Management of Occupational Exposure to Engineered Nanoparticles Through a Chance-Constrained Nonlinear Programming Approach

Supercritical Extraction of Carotenoids from Rosa canina L. Hips and their Formulation with β-Cyclodextrin

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Ultrasound-Enhanced Subcritical CO₂ Extraction of Lutein from Chlorella pyrenoidosa

Ultrasound-Enhanced Subcritical CO₂ Extraction of Lutein from Chlorella pyrenoidosa