Process Optimization for the Preparation of Beta-cyhalothrin Microspheres by Using the Response Surface Methodology

Yang, Jinghan; Feng, Jianguo; Sun, Chencheng; Chen, Wang; Ma, Yingjian; Chen, Ziyang; Dong, Sa; Deng, Wei

doi:10.1007/s10924-021-02107-4

Cited by 6 publications

(6 citation statements)

References 39 publications

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“…If the appearance of the microsphere surface is damaged or incomplete, both the EE and the final insecticidal efficiency will be decreased. 32 The morphological observation of SP microspheres by SEM showed that the microspheres were spherical in shape with surface integrity, and had good dispersibility and uniformity (no severe adhesion phenomenon was observed). According to Wang's report, 33 however, as the particle size decreased, drug release of microspheres increased owing to higher SSA, as did biological activity of microspheres.…”

Section: Discussionmentioning

confidence: 91%

Preparation of a long‐lasting tablet of spinosad microspheres and its residual insecticidal efficacy against the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae) larvae

Yu,

Li,

Wang

et al. 2024

Pest Management Science

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BACKGROUNDSTo provide a long‐lasting formulation for spinosad (SP) targeting larval stages of Aedes aegypti (Linnaeus) and others alike, a SP tablet was developed based on microspheres, using polylactic acid as inside coating material. The microspheres were encapsulated using polyethylene glycol and 1‐hexadecanol to form a sustained‐release SP tablet. Micromorphology, active ingredient loading, structure identification, photolysis resistance, and biological activity were evaluated in this report.RESULTS(1) SP microspheres have an average particle size of 6.16 ± 2.28 μm, low adhesion, and good dispersion as evaluated by scanning electron microscopy (SEM) and morphology; (2) The average active ingredient loading and encapsulation of SP microspheres were 32.80 ± 0.74% and 78.41 ± 2.22%, respectively; (3) The chemical structure of encapsulated SP was confirmed by FT‐IR and 1H‐NMR; (4) The photostability of the microspheres and the tablets were evaluated. The results showed that DT50 (time required to dissipate 50% of the mass originally present) of SP was 0.95 days in microspheres and 6.94 days in tablets. (5) The long‐term insecticidal activity of SP tablets was investigated, and the tablet had a long‐lasting activity against the mosquito larvae, showing 100% larval mortality for 63 days.CONCLUSIONSThe study provided a new long‐lasting formulation of SP which displayed good efficacy in the control of Ae. aegypti larvae.This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 91%

Preparation of a long‐lasting tablet of spinosad microspheres and its residual insecticidal efficacy against the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae) larvae

Yu,

Li,

Wang

et al. 2024

Pest Management Science

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“…This was consistent with the data listed in Table , where the significant effects on the encapsulation were found in the order of CTS concentration, mass ratio, and CAP concentration. Different from the approximately circular curves in Figure b,d, an elliptical contour was observed in Figure f, indicating that the combined effect of mass ratio and CAP concentration is significant. , From the above experimental design, the optimal conditions of the three factors for the formulation preparation should be 0.89% CTS, 1.55% CAP, and a mass ratio of CTS to CAP of 1.76:1. Under these conditions, the weight of controlled release microparticles in CCF prepared from 0.15 g of CAP and 0.26 g of CTS was about 0.40 g. The LC and EE of the resulting formulation were determined to be about 28.39 ( s = 0.39%, n = 3) and 75.71% ( s = 1.03%, n = 3), respectively.…”

Section: Resultsmentioning

confidence: 99%

Chitosan-Delivered Chlorantraniliprole for Pest Control: Preparation Optimization, Deposition Behavior, and Application Potential

Liu,

Wang,

Luo

et al. 2023

ACS Omega

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Chitosan has emerged as a promising biopolymer carrier for the sustained release of pesticides owing to its good biocompatibility, biodegradability, and bioactivity. In this work, a controlled-release formulation of insecticide chlorantraniliprole was fabricated through coprecipitation-based synchronous encapsulation with chitosan, where the optimum preparation conditions, storage stability, deposition behavior, and application potential were investigated. Preparation of optimization data from response surface methodology showed high correlation coefficient (R 2) of 0.9875 and adjusted coefficient (R adj 2) of 0.9715. The resulting formulation displayed good loading content of 28.39%, high encapsulation efficiency of 75.71%, and good storage stability. Compared with the commercial suspension concentrate, the formulation exhibited better wettability and retention behaviors on plant leaves. Excitingly, effective control against one species of mealybug genus Paraputo Laing (outside the killing spectrum) on the Hippeastrum reticulatum plant was successfully achieved by spraying the controlled-release formulation at different time intervals. This work indicates the good potential of the developed formulation in expanding the application scope of chlorantraniliprole, which shows a new strategy for sustainable pest management.

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“…5 μL of the solution was injected into the HPLC system and separated at 25 °C using a constant flow rate of 1.0 mL/min at a detection wavelength of 230 nm. The encapsulation efficiency (EE %) of lambda-cyhalothrin was calculated according to the following eq D L .25em ( % ) = 0.975 × A a × m b m a × A b × 100 normalX ( % ) = D L .25em % × m a × A c m c × A a × 100 E E .25em ( % ) = D L − normalX normalD normalL × 100 where A a is the peak area of lambda-cyhalothrin in the disrupted microcapsule suspension, A b is the peak area of lambda-cyhalothrin in the standard solution, A c is the peak area of lambda-cyhalothrin in the extraction solution, m a is the mass of the disrupted microcapsule suspension, m b is the mass of lambda-cyhalothrin in the standard solution, and m c is the mass of the lambda-cyhalothrin microcapsule suspension for extraction. X % was the content of lambda-cyhalothrin outside of the microcapsule, and DL % was the drug-loading content of the microcapsule.…”

Section: Methodsmentioning

confidence: 99%

Section: Measurements Of Encapsulation Efficiency (Ee %mentioning

confidence: 99%

Preparation, Characterization, and Bioactivity Evaluation of Lambda-Cyhalothrin Microcapsules for Slow-Controlled Release System

Wang,

Liu,

Gao

et al. 2024

ACS Omega

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The utilization of interfacial polymerization in the preparation of microcapsules with a slow-controlled release has been shown to effectively improve pesticide efficacy and reduce environmental pollution. In this study, polyurea microcapsules loaded with lambda-cyhalothrin were prepared by an interfacial polymerization method using modified isocyanate (MDI) as the wall material and GT-34 as the initiator. The microcapsules were fully characterized by optical microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, etc., and release behaviors were investigated. The results indicated that the microcapsules had a smooth surface and uniform distribution, the average particle size of the microcapsules was 1.97 μm, and the encapsulation efficiency of lambda-cyhalothrin microcapsules could reach 91.48%. Compared with other commercial formulations, the microcapsules exhibited an excellent sustained release property (>7 days) in a 50% acetonitrile aqueous solution (v/v). Subsequently, in vitro release studies showed that the lambda-cyhalothrin microcapsules could consistently control the release of the core materials at different pH, temperature, and MDI addition amount conditions. The release of lambda-cyhalothrin microcapsules was in accordance with the first-order model release, which was mainly by the Fickian diffusion mechanism. Furthermore, the biological activity on Myzus persicae showed that the microcapsules’ persistence period was above 21 days, which was longer than that for the emulsifiable concentrate formulation.

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Process Optimization for the Preparation of Beta-cyhalothrin Microspheres by Using the Response Surface Methodology

Cited by 6 publications

References 39 publications

Preparation of a long‐lasting tablet of spinosad microspheres and its residual insecticidal efficacy against the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae) larvae

Preparation of a long‐lasting tablet of spinosad microspheres and its residual insecticidal efficacy against the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae) larvae

Chitosan-Delivered Chlorantraniliprole for Pest Control: Preparation Optimization, Deposition Behavior, and Application Potential

Preparation, Characterization, and Bioactivity Evaluation of Lambda-Cyhalothrin Microcapsules for Slow-Controlled Release System

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