Trapezoidal threaded spindles are ideal for supporting heavy loads and are therefore frequently used in heavy-duty lifting systems. Both the forming thread rolling process and the machining thread whirling process can be used to manufacture these lead screws. In order to improve the low efficiency of trapezoidal screw drives, it is crucial to understand and minimize friction losses. As part of a cooperation project between the Institute of Production Engineering and Machine Tools (IFW) and Bornemann Gewindetechnik, research was carried out into adapting the whirling process to optimize the tribological properties of threaded spindles. The process developed makes it possible to reduce the coefficient of friction in trapezoidal screw drives and thus also the required torque. By using whirled microtextures, the friction loss can be reduced by 25.5% and adhesive wear can be significantly reduced.