Processes regulating the initiation and postejaculatory resumption of copulatory behavior in male hamsters

Floody, Owen R.

doi:10.1016/j.beproc.2014.03.008

Cited by 3 publications

(3 citation statements)

References 13 publications

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“…The majority of the studies on sexual behavior have been completed in rats due to their availability, and well-defined sequence of copulatory behavior and its parameters (i.e., the number of mounts and intromissions of the penis into the vagina in a series of copulatory activity starting with a mount and ending with ejaculation, and the post ejaculatory interval, the time interval between an ejaculation and the beginning of a new series of copulatory activity) in the male (see [ 72 , 73 , 74 , 232 , 233 , 234 ]) and of the well-defined proceptive and receptive behavior in the female, the first being characterized by the first by darts, hops, and ear wiggling episodes, and the second of which being defined by lordosis (e.g., arching of the female back when the male mounts the female from back and touches her flanks and deflection of the tail to one side) (see [ 235 , 236 ]). However, extensive data on sexual behavior are also available for other mammals, i.e., mice (see [ 237 , 238 ]), hamsters [ 239 ], prairie and montane voles (see [ 240 ]), monkeys [ 241 ], and other animal species as well, i.e., the Japanese quail (see [ 242 , 243 ]) and the zebra finch (see [ 244 ]).…”

Section: Oxytocin and Sexual Behaviormentioning

confidence: 99%

Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances

Melis

Argiolas

2021

IJMS

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A continuously increasing amount of research shows that oxytocin is involved in numerous central functions. Among the functions in which oxytocin is thought to be involved are those that play a role in social and sexual behaviors, and the involvement of central oxytocin in erectile function and sexual behavior was indeed one of the first to be discovered in laboratory animals in the 1980s. The first part of this review summarizes the results of studies done in laboratory animals that support a facilitatory role of oxytocin in male and female sexual behavior and reveal mechanisms through which this ancient neuropeptide participates in concert with other neurotransmitters and neuropeptides in this complex function, which is fundamental for the species reproduction. The second part summarizes the results of studies done mainly with intranasal oxytocin in men and women with the aim to translate the results found in laboratory animals to humans. Unexpectedly, the results of these studies do not appear to confirm the facilitatory role of oxytocin found in male and female sexual behavior in animals, both in men and women. Possible explanations for the failure of oxytocin to improve sexual behavior in men and women and strategies to attempt to overcome this impasse are considered.

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Section: Oxytocin and Sexual Behaviormentioning

confidence: 99%

Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances

Melis

Argiolas

2021

IJMS

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“…The studies on male sexual behavior have usually been and are still performed mainly in rats because of their availability and the well-characterized sequence of copulatory behavior and its parameters [ 59 , 60 , 165 , 166 ]. However, data on male sexual behavior in other animal species (mice, rabbits, hamsters, voles, primates, and even birds, as the Japanese quail and the zebra finch) are also available [ 61 , 167 , 168 , 169 , 170 , 171 , 172 ]. Penile erection, seminal emission and ejaculation are the main components of the consummatory phase of the male sexual response and are preceded by an anticipatory phase, which includes motivation towards and searching for an adequate partner for copulation [ 59 , 60 , 173 ].…”

Section: Central No and Male Sexual Behaviormentioning

confidence: 99%

Erectile Function and Sexual Behavior: A Review of the Role of Nitric Oxide in the Central Nervous System

Melis

Argiolas

2021

Biomolecules

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Nitric oxide (NO), the neuromodulator/neurotransmitter formed from l-arginine by neuronal, endothelial and inducible NO synthases, is involved in numerous functions across the body, from the control of arterial blood pressure to penile erection, and at central level from energy homeostasis regulation to memory, learning and sexual behavior. The aim of this work is to review earlier studies showing that NO plays a role in erectile function and sexual behavior in the hypothalamus and its paraventricular nucleus and the medial preoptic area, and integrate these findings with those of recent studies on this matter. This revisitation shows that NO influences erectile function and sexual behavior in males and females by acting not only in the paraventricular nucleus and medial preoptic area but also in extrahypothalamic brain areas, often with different mechanisms. Most importantly, since these areas are strictly interconnected with the paraventricular nucleus and medial preoptic area, send to and receive neural projections from the spinal cord, in which sexual communication between brain and genital apparatus takes place, this review reveals that central NO participates in concert with neurotransmitters/neuropeptides to a neural circuit controlling both the consummatory (penile erection, copulation, lordosis) and appetitive components (sexual motivation, arousal, reward) of sexual behavior.

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“…In mammals, it is generally accepted that it occurs in two main phases, anticipatory and consummatory, and different quantifiable parameters have been identified in each phase and in males and females [ 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 ]. These studies were done mainly in rats because of their availability, the well-characterized sequence of copulatory behavior and its parameters in the male (for a detailed description of the male rat copulatory behavior see [ 87 , 173 , 174 , 175 , 176 ]), and of proceptive and receptive (lordotic) behavior in the female (see [ 177 , 178 ]), although data on other animal species are also available [ 179 , 180 , 181 , 182 , 183 , 184 , 185 ]. Penile erection, mounts and intromissions, seminal emission and ejaculation characterize the consummatory phase of male sexual response, whereas vaginal lubrication, clitoris erection and orgasm are typical of female sexual response.…”

Section: Dopamine and Sexual Behaviormentioning

confidence: 99%

Dopamine, Erectile Function and Male Sexual Behavior from the Past to the Present: A Review

2022

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Early and recent studies show that dopamine through its neuronal systems and receptor subtypes plays different roles in the control of male sexual behavior. These studies show that (i) the mesolimbic/mesocortical dopaminergic system plays a key role in the preparatory phase of sexual behavior, e.g., in sexual arousal, motivation and reward, whereas the nigrostriatal system controls the sensory-motor coordination necessary for copulation, (ii) the incertohypothalamic system is involved in the consummatory aspects of sexual behavior (penile erection and copulation), but evidence for its role in sexual motivation is also available, (iii) the pro-sexual effects of dopamine occur in concert with neural systems interconnecting the hypothalamus and preoptic area with the spinal cord, ventral tegmental area and other limbic brain areas and (iv) D2 and D4 receptors play a major role in the pro-sexual effects of dopamine. Despite some controversy, increases or decreases, respectively, of brain dopamine activity induced by drugs or that occur physiologically, usually improves or worsens, respectively, sexual activity. These findings suggest that an altered central dopaminergic tone plays a role in mental pathologies characterized by aberrant sexual behavior, and that pro-erectile D4 receptor agonists may be considered a new strategy for the treatment of erectile dysfunction in men.

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Processes regulating the initiation and postejaculatory resumption of copulatory behavior in male hamsters

Cited by 3 publications

References 13 publications

Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances

Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances

Erectile Function and Sexual Behavior: A Review of the Role of Nitric Oxide in the Central Nervous System

Dopamine, Erectile Function and Male Sexual Behavior from the Past to the Present: A Review

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