2012
DOI: 10.1002/pen.23329
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Processing and properties of hydrophilic electrospun polylactic acid/beta‐tricalcium phosphate membrane for dental applications

Abstract: Typical electrospun polylactic acid (PLA) membranes revealing potential hydrophobicity and inflammation from acid release during degradation are major drawbacks as an ideal guided tissue regeneration (GTR) barrier. This study investigated the in vitro degradation properties of electrospun PLA/beta‐tricalcium phosphate (β‐TCP) membranes treated by polyethylene oxide dip‐coating process. After surface modification, the membranes revealed good wettability in contact angle measurement. The addition of β‐TCP can re… Show more

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Cited by 19 publications
(18 citation statements)
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“…We observe a slight decrease in the Table 3 Figure 5 (G') is detected at temperatures higher than 90-100 ºC; this is related to the cold crystallization process which leads to increased crystallinity and, subsequently, an increase in stiffness is achieved. As we can clearly detect, the crystallization moves to lower temperatures as the β-TCP content increases due to the nucleating effect of finely dispersed β-TCP into the PLA polymeric matrix (37). …”
Section: Figurementioning
confidence: 79%
“…We observe a slight decrease in the Table 3 Figure 5 (G') is detected at temperatures higher than 90-100 ºC; this is related to the cold crystallization process which leads to increased crystallinity and, subsequently, an increase in stiffness is achieved. As we can clearly detect, the crystallization moves to lower temperatures as the β-TCP content increases due to the nucleating effect of finely dispersed β-TCP into the PLA polymeric matrix (37). …”
Section: Figurementioning
confidence: 79%
“…The ES PLA95/β-TCP membranes were prepared using dip-coating technique with a dimension of 3.0 × 4.0 cm 2 (width × length), thickness of 0.3–0.4 mm, suture pull-out force of >200 gf, average porosity of 53.0 ± 4.5%, and average pore size of 25.0 ± 1.0 µm. Unlike the ES PLA95/β-TCP-N with contact angle of 122.6 ± 0.1°, the PEO (polyethylene oxide) dip-coated ES PLA95/β-TCP-T revealed the contact angle of 50.7 ± 0.2° [22]. The hydrophilic surface would help cell adhesion to prevent the membrane expose and avoid infection during healing process.…”
Section: Resultsmentioning
confidence: 99%
“…In this study, we prepared the PLA95/β-TCP GTR membranes by ES and dip-coating techniques [22], then the safety and effectiveness of this GTR membrane were assayed by cytotoxicity testing, in vivo, and clinical studies.…”
Section: Introductionmentioning
confidence: 99%
“…Compared to petroleum‐based polymers, PLA possesses considerable mechanical properties, good processability, excellent biodegradability, and readily available raw materials . To date, PLA has been widely used in agricultural, industrial, and medical fields, such as food packaging, horticulture crop containers, and biological tissue scaffolds, as well as in emerging 3D printing applications . PLA can also be degraded into water, carbon dioxide, and other small molecules under environmental conditions.…”
Section: Introductionmentioning
confidence: 99%