Processing biological samples from simulated radiological terrorist events using Rapid DNA instruments

Frégeau, Chantal J.; Laurin, Nancy

doi:10.1016/j.forsciint.2023.111887

Forensic Science International

2024

DOI: 10.1016/j.forsciint.2023.111887

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Processing biological samples from simulated radiological terrorist events using Rapid DNA instruments

Chantal J. Frégeau,

Nancy Laurin

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2024

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Toward Analysis at the Point of Need: A Digital Microfluidic Approach to Processing Multi‐Source Sexual Assault Samples

Elsayed,

Bodo,

Gaoiran

et al. 2024

Advanced Science

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Forensic case samples collected in sexual assaults typically contain DNA from multiple sources, which complicates short‐tandem repeat (STR) profiling. These samples are typically sent to a laboratory to separate the DNA from sperm and non‐sperm sources prior to analysis. Here, the automation and miniaturization of these steps using digital microfluidics (DMF) is reported, which may eventually enable processing sexual assault samples outside of the laboratory, at the point of need. When applied to vaginal swab samples collected up to 12 h post‐coitus (PC), the new method identifies single‐source (male) STR profiles. When applied to samples collected 24–72 h PC, the method identifies mixed STR profiles, suggesting room for improvement and/or potential for data deconvolution. In sum, an automated, miniaturized sample pre‐processing method for separating the DNA contained in sexual assault samples is demonstrated. This type of automated processing using DMF, especially when combined with Rapid DNA Analysis, has the potential to be used for processing of sexual assault samples in hospitals, police offices, and other locations outside of the laboratory.

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Toward Analysis at the Point of Need: A Digital Microfluidic Approach to Processing Multi‐Source Sexual Assault Samples

Elsayed,

Bodo,

Gaoiran

et al. 2024

Advanced Science

View full text Add to dashboard Cite

show abstract

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Processing biological samples from simulated radiological terrorist events using Rapid DNA instruments

Cited by 1 publication

References 40 publications

Toward Analysis at the Point of Need: A Digital Microfluidic Approach to Processing Multi‐Source Sexual Assault Samples

Toward Analysis at the Point of Need: A Digital Microfluidic Approach to Processing Multi‐Source Sexual Assault Samples

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