2022
DOI: 10.1007/s11010-022-04359-7
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Processing body (P-body) and its mediators in cancer

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Cited by 13 publications
(9 citation statements)
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“… 68 , 257 P bodies are responsible for RNA decay and storage, and different components of P bodies play different roles in tumorigenesis. 258 Emerging evidence also demonstrates that abnormalities in the expression and/or activity of SG components contribute to drug resistance and the tumorigenesis of diverse cancers, including CRC, 259 pancreatic cancer, 260 and leukemia. 261 Furthermore, YTHDC1 in the nucleus can undergo LLPS by binding with m 6 A-mRNA (Fig.…”
Section: Aberrant Llps In Cancermentioning
confidence: 99%
See 1 more Smart Citation
“… 68 , 257 P bodies are responsible for RNA decay and storage, and different components of P bodies play different roles in tumorigenesis. 258 Emerging evidence also demonstrates that abnormalities in the expression and/or activity of SG components contribute to drug resistance and the tumorigenesis of diverse cancers, including CRC, 259 pancreatic cancer, 260 and leukemia. 261 Furthermore, YTHDC1 in the nucleus can undergo LLPS by binding with m 6 A-mRNA (Fig.…”
Section: Aberrant Llps In Cancermentioning
confidence: 99%
“…P-body-based regulation of mRNA metabolism plays an important role in cancer development and progression. 258 2. SG assembly is upregulated in cancer.…”
Section: Introductionmentioning
confidence: 99%
“…The regulation of mRNA decay in tumors is complex. On the one hand, cancer cells utilize the decay mechanism to suppress the expression of tumor suppressor genes, and on the other hand, cancer cells suppress the decay mechanism to adapt to their microenvironment [ 23 ].…”
Section: Introductionmentioning
confidence: 99%
“…Processing bodies (P-bodies) are dynamic cytoplasmic RNP (ribonucleoprotein) granules that contain nontranslatable mRNAs in complex with proteins involved in translation repression and mRNA decay in eukaryotic cells [ 23 ]. P-bodies are conserved in eukaryotes and share similarities with other RNP granules, such as Cajal bodies and stress granules, and their formation relies on a complex network of protein-RNA interactions, low-complexity protein sequences and liquid-liquid phase separations (LLPS) [ 24 ].…”
Section: Introductionmentioning
confidence: 99%
“…LLPS mediates the epigenetic expression by providing the adaptability of the cellular microenvironment according to the cellular stress (2). LLPS is formed by the interaction between RNAs-RNAs, RNAs-protein, ribonucleoprotein, proteins-proteins, and non-coding RNAs interaction, which subsequently results in the formation of dynamic condensates (3)(4)(5).…”
Section: Introductionmentioning
confidence: 99%