Processing, characterisation and biocompatibility of iron-phosphate glass fibres for tissue engineering

Ahmed, Ifty; Collins, Charlotte; Lewis, Mark P.; Olsen, I; Knowles, Jonathan C.

doi:10.1016/j.biomaterials.2003.10.013

Cited by 209 publications

(221 citation statements)

References 15 publications

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“…PGFs are able to dissolve completely within aqueous media and their dissolution rate can be adjusted easily by altering the glass composition [2]. Fibres with mechanical properties between 500-1200 MPa and 60-80 GPa for tensile strength and modulus respectively, have been achieved which are comparable to commercially available Eglass fibre [8][9][10]. As an example, PLA/ unidirectional (UD) PGF composites plates with fibre volume fractions (Vf) of 35% and 50% have been produced, which showed flexural strength values of ~116 MPa, ~170 MPa and flexural modulus values of ~16 GPa and ~15 GPa, respectively [11,12].…”

Section: Introductionmentioning

confidence: 94%

“…Biocompatibility of both PCL (approved by FDA) and of phosphate based glass fibre (PGF) has been well investigated and both are known to be bioresorbable, which makes these materials favourable candidates for bone repair applications [3][4][5][6]. Most recently, PGF has been used as reinforcement for developing fully bioresorbable polymer composites [2,7,8]. PGFs are able to dissolve completely within aqueous media and their dissolution rate can be adjusted easily by altering the glass composition [2].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

Chen

Parsons

Felfel

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Fully bioresorbable composites have been investigated in order to replace metal implant plates used for hard tissue repair. Retention of the composite mechanical properties within a physiological environment has been shown to be significantly affected due to loss of the integrity of the fibre/matrix interface. This study investigated phosphate based glass fibre (PGF) reinforced polycaprolactone (PCL) composites with 20%, 35% and 50% fibre volume fractions (Vf) manufactured via an in-situ polymerisation (ISP) process and a conventional laminate stacking (LS) followed by compression moulding. Reinforcing efficiency between the LS and ISP manufacturing process was compared, and the ISP composites revealed significant improvements in mechanical properties when compared to LS composites. The degradation profiles and mechanical properties were monitored in phosphate buffered saline (PBS) at 37°C for 28 days. ISP composites revealed significantly less media uptake and mass loss (p<0.001) throughout the degradation period. The initial flexural properties of ISP composites were substantially higher (p<0.0001) than those of the LS composites, which showed that the ISP manufacturing process provided a significantly enhanced reinforcement effect than the LS process. During the degradation study, statistically higher flexural property retention profiles were also seen for the ISP composites compared to LS composites. SEM micrographs of fracture surfaces for the LS composites revealed dry fibre bundles and poor fibre dispersion with polymer rich zones, which indicated poor interfacial bonding, distribution and adhesion. In contrast, evenly distributed fibres without dry fibre bundles or polymer rich zones, were clearly observed for the ISP composite samples, which showed that a superior fibre/matrix interface was achieved with highly improved adhesion.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

Chen

Parsons

Felfel

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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“…Phosphate glasses based on the ternary P 2 O 5 -CaO-Na 2 O system have the potential to be used as scaffold materials. They are degradable and the degradation rate is strongly dependant on composition, and accordingly a wide range of materials with different degradation rates can be obtained by tailoring the glass chemistry [2][3][4]. Furthermore, their degradation products can be eliminated by the normal physiological mechanisms of the body [5].…”

Section: Introductionmentioning

confidence: 99%

Doping of a high calcium oxide metaphosphate glass with titanium dioxide

Neel

Chrzanowski

Valappil

et al. 2009

Journal of Non-Crystalline Solids

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a b s t r a c tThis study investigates the effect of doping a high calcium oxide containing metaphosphate glass series (CaO) 40 (Na 2 O) 10 (P 2 O 5 ) 50 with TiO 2 (1, 3, and 5 mol%). TiO 2 incorporation increased the density and glass transition temperature while reduced the degradation rate (5 mol% in particular) by twofold compared with (CaO) 30 system reported previously. This has been confirmed by ion release and the minimal pH changes. TiP 2 O 7 , NaCa(PO 3 ) 3 and CaP 2 O 6 phases were detected for all TiO 2 -containing ceramics. XPS showed that the surface is composed of Ca, P, and Ti. Ti was recognized mainly as TiO 2 , but its total amount was lower than theoretical values. 31 P magic angle spinning (MAS) NMR showed a downfield shift of the 31 P lineshape with increasing TiO 2 , interpreted as an effect of the titanium cation rather than an increase in the phosphate network connectivity. FTIR showed that incorporation of TiO 2 increased the strength of the phosphate chains, and the O/P ratio while introducing more Q 1 units into the structure at the expense of the Q 2 units. There were no differences, however, in surface topography roughness and free energies between these glasses. These results suggested that TiO 2 and CaO were acting synergistically in producing glasses with controllable bulk and structural properties.

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“…implants or tissue engineering devices, which are suppose to satisfy these definitions, polymers, ceramics, and glasses or combination of those materials [1][2][3][4][5][6][7] are the most popular. Some of these materials are very well established and commonly used to produce various medical devices.…”

mentioning

confidence: 99%

“…[24,[35][36][37][38][39][40] It is envisaged that phosphate glasses in various forms may be applicable for load bearing implants (fiber reinforced composite materials-under development; data unpublished), wound healing dressings (antimicrobial activity) or bioadesives. [16] Referring to the definitions presented by Ratner and literature review, the use of doped phosphate glasses in combination with other materials seems to be particularly relevant for biomaterials especially for bone tissue application (implants, coatings).…”

mentioning

confidence: 99%

Tailoring Cell Behavior on Polymers by the Incorporation of Titanium Doped Phosphate Glass Filler

et al. 2010

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Understanding tissue response to materials, to enable modulation and guided tissue regeneration is one of the main challenges in biomaterials science. Nowadays polymers, glasses, and metals dominate as biomaterials. Often native properties of those materials are not sufficient and there is a need to combine them, so as to modify and adjust their properties to the application. The primary aim of this study was to improve cell response to polymer (PLDL) using phosphate glass as filler (titanium doped phosphate glass). As a control β‐tricalcium phosphate (TCP) filler was used. Various concentrations of the filler were used (10–40 vol%). Wetting behavior, ζ‐potentials, mechanical and thermal properties, and human cells response to the materials were evaluated. Results showed that with increase in glass filler loading wettability improved, ζ‐potentials dropped, and increase in stiffness of materials was observed. Importantly cell culture experiments showed more developed and well spread cells on the samples with glass content up to 20 vol%. Cells responded much more positively to the glass filled samples than to TCP filled. However, expression of osteocalcin and osteopontin, proteins that indicate formation of the mineralized structures was positive for all the samples including pure PLDL. It was concluded that due to improved wetting behavior, lower ζ‐potentials, and specific chemistry of the glass filler it was possible to alter cells response, improve bioactivity of the polymer, and vary mechanical properties.

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Processing, characterisation and biocompatibility of iron-phosphate glass fibres for tissue engineering

Cited by 209 publications

References 15 publications

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

In-situ polymerisation of fully bioresorbable polycaprolactone/phosphate glass fibre composites: In vitro degradation and mechanical properties

Doping of a high calcium oxide metaphosphate glass with titanium dioxide

Tailoring Cell Behavior on Polymers by the Incorporation of Titanium Doped Phosphate Glass Filler

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