Processing, Characterization and Application of Some Borophosphate Glasses Containing Antibacterial and Antifungal Oxides in Bioactive Demands

Abstract

A SERIES of borophosphate glasses doped individually with few antimicrobial oxides; CeO 2 , ZnO and CuO were prepared by melt quenching technique. The structure and bioactivity of the prepared samples were analyzed through FTIR spectral technique and corrosion behavior before and after immersion for 2 weeks in simulated body fluid (SBF) under static condition. The microstructure of the glass was examined using SEM to confirm the bioactivity of glass through the formation of calcium phosphate (CaP) layer on the surface. FTIR spectra of the glass after immersion in SBF show characteristic peaks of calcium phosphate. Weight loss% display a difference in solubility in the SBF solution in relation to the antibacterial oxide added. SEM results show clear nodular microcrystalline calcium phosphate. The prepared glasses revealed effect against some microbes and bacteria. It was established that the addition of the antimicrobial oxides had a positive effect on the glass bioactivity and may find a part in the biomedical applications.

Scaffolds in the microbial resistant era: Fabrication, materials, properties and tissue engineering applications

“…These fiber mats would be suitable for the management of superficial fungal infections of the cornea and corneal tissue regeneration [ 392 ]. Borophosphate glasses doped individually with a few antimicrobial oxides such as CeO 2 , ZnO and CuO were prepared by the melt quenching technique [ 391 ]. The results revealed antimicrobial activity against some fungi and bacteria, that the addition of the antimicrobial oxides had a positive effect on the glass bioactivity and could play a part in biomedical applications [ 391 ].…”

“…Borophosphate glasses doped individually with a few antimicrobial oxides such as CeO 2 , ZnO and CuO were prepared by the melt quenching technique [ 391 ]. The results revealed antimicrobial activity against some fungi and bacteria, that the addition of the antimicrobial oxides had a positive effect on the glass bioactivity and could play a part in biomedical applications [ 391 ]. In another study, the deposition of Ag/HAp thin films on Ti modified with TiO 2 nanotubes substrates, followed by a heat treatment at 500 ​°C in water vapor for 6 ​h, produced efficient antifungal shield barriers for treating bone defects [ 389 ].…”

“…The scaffold showed effective antifungal behavior in an in vivo study (mouse model) as well as good biocompatibility [ 395 ], indicating a good potential for wound healing. Cytotoxicity studies were carried out on general-purpose antifungal scaffolds for tissue engineering using several cell lines such as MSCs [ 390 ], fibroblasts [ 360 , 393 ], human endothelial cells, human carcinoma cells [ 389 ] and human endothelial cells [ 394 ], although biocompatibility assays were not reported in several studies [ 384 , 385 , 387 , 388 , 391 , 396 , 398 ].…”

Synergetic tellurium influence on aluminium borophosphate glass material for structural and antimicrobial activities

“…[18][19][20][21] Tellurium is valued in a variety of applications, including the treatment of bone defects, tissue engineering, therapeutic usage, infected frontal sinuses, and hypersensitive teeth. [22,23] Glass forming oxides with dependable biological and optical properties include B 2 O 3 . The presence of both borate and phosphate species in a system can give it stability and even bioactivity.…”