Processing conditions and characterization of novel electrospun poly (3-hydroxybutyrate-co-hydroxyvalerate)/chitosan blend fibers

Nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/chitosan scaffolds for skin regeneration

“…The PHBV/chitosan blends were dissolved in a TFA/HFIP 1:1 (v/v) as co-solubilization and good electrospinnability was achieved using this solvent. As previously observed [15], both mats showed a typical non-woven nanofibrous structure and high porosity. Total reflection-Fourier transform infrared spectroscopy analysis confirmed that both PHBV and chitosan were distributed in the hybrid nanofibers and the occurrence of intermolecular hydrogen bonds between the polymers.…”

“…In the present work, two PHBV/chitosan blends were selected (PHBV/C [4:1] and PHBV/C [2:3]) based on the morphological and degradation differences previously observed [15], and their potential as scaffolds for skin engineering was studied. Fig.…”

“…PHBV/chitosan scaffolds were prepared as previously described [15]. PHBV/chitosan (4:1 or 2:3 (w/w), total polymer mass of 10%) solutions in trifluoracetic acid/1,1,1,3,3,3-hexafluoro-2-isopropanol (1:1, v/v) were electrospun at 22 kV applied voltage, with a flow rate of 8 L/min and a needle tip-to-collector distance of 14 cm, using a rotating drum (900 rpm) as the collector.…”

“…PHBV grafted with chitosan and oligochitosans has shown improved protein adsorption and fibroblast attachment in vitro [13,14]. Recently, our group has developed hybrid nanofibers of PHBV/chitosan by electrospinning [15]. Manipulation of polymer ratio, solvent composition and chitosan molecular weight proved to be an effective way to control the scaffolds architecture.…”

What Changes in Poly(3-Hydroxybutyrate) (PHB) When Processed as Electrospun Nanofibers or Thermo-Compression Molded Film?

“…The fiber jet travels through the atmosphere allowing the solvent to evaporate, thus leading to the solid polymer fibers deposition on the collector 5 . Blends of several ratios of poly(3-hydroxybutyrate-cohydroxyvalerate) (PHBV) and chitosan were electrospun to produce fibrous membranes 6 . In this case, the goal was to combine these two biocompatible and biodegradable polymers, thus creating a new material with potential biomedical application.…”