Processing of Bioactive Glass Scaffolds for Bone Tissue Engineering

Fiume, Elisa; Migneco, Carla; Kargozar, Saeid; Verné, Enrica; Baino, Francesco

doi:10.1002/9781119724193.ch7

Bioactive Glasses and Glass‐Ceramics 2022

DOI: 10.1002/9781119724193.ch7

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Processing of Bioactive Glass Scaffolds for Bone Tissue Engineering

Elisa Fiume

Carla Migneco

Saeid Kargozar

et al.

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Cited by 2 publications

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XRD, EDX and FTIR study of the bioactivity of 60S GLASS doped with La and Y under in vitro conditions

Kusyak¹,

Oranska²,

Behunova³

et al. 2023

Him. Fiz. Tehnol. Poverhni

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The aim of the work is the synthesis and study of the bioactivity of sol-gel glass (BG 60S) with molar composition 60 % SiO2, 36 % CaO, 4 % P2O5 and samples doped with La and Y in vitro; studying their structural properties and changes upon contact with a model physiological environment (Kokubo’s SBF), as well as justifying the possibility of their use for tissue regeneration and tissue engineering. According to the results of research, the interaction of synthesized samples with SBF leads to a change in the phase composition and the ratio of amorphous and crystalline components. It is necessary to note long and intensive processes involving CO32– ions for unalloyed and alloyed samples. The appearance of calcium carbonate in the form of vaterite with a simultaneous increase in the calcite content is one of the signs of high bioactivity of the synthesized samples. According to the results of XRD, EDX and FTIR studies after 28 days of soaking in SBF, the predominant surface elements are Ca and P in the composition of hydroxyapatite, and the elemental composition indicates active ion exchange processes according to the theory of bioactive glass dissolution in physiological fluids. The change in the ratio of crystalline phases with the inclusion of mainly one crystalline phase of hydroxopatite within 28 days leads to a better structuredness of the surface of the synthesized samples and indicates that they have osteoconductive properties, can connect with bone tissue and have the appropriate biodegradation ability. The results of the study indicate the promising nature of synthesized materials for tissue regeneration and tissue engineering.

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XRD, EDX and FTIR study of the bioactivity of 60S GLASS doped with La and Y under in vitro conditions

Kusyak¹,

Oranska²,

Behunova³

et al. 2023

Him. Fiz. Tehnol. Poverhni

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Alginate-Sr/Mg Containing Bioactive Glass Scaffolds: The Characterization of a New 3D Composite for Bone Tissue Engineering

Guagnini,

Medagli,

Zumbo

et al. 2024

JFB

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In bone regeneration, combining natural polymer-based scaffolds with Bioactive Glasses (BGs) is an attractive strategy to improve the mechanical properties of the structure, as well as its bioactivity and regenerative potential. Methods: For this purpose, a well-studied alginate/hydroxyapatite (Alg/HAp) porous scaffold was enhanced with an experimental bioglass (BGMS10), characterized by a high crystallization temperature and containing therapeutic ions such as strontium and magnesium. This resulted in an improved biological response compared to 45S5 Bioglass®, the “gold” standard among BGs. Porous composite scaffolds were fabricated by freeze-drying technique and characterized by scanning electron microscopy and microanalysis, infrared spectroscopy, and microcomputed tomography. The mechanical properties and cytocompatibility of the new scaffold composition were also evaluated. The addition of bioglass to the Alg/HAp network resulted in a slightly lower porosity. However, despite the change in pore size, the MG-63 cells were able to better adhere and proliferate when cultured for one week on a BG scaffold compared to the control Alg/HAp scaffolds. Thus, our findings indicate that the combination of bioactive glass BGMS10 does not affect the structural and physicochemical properties of the Alg/HAp scaffold and confers bioactive properties to the structures, making the Alg/HAp-BGMS10 scaffold a promising candidate for future application in bone tissue regeneration.

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Processing of Bioactive Glass Scaffolds for Bone Tissue Engineering

Cited by 2 publications

References 93 publications

XRD, EDX and FTIR study of the bioactivity of 60S GLASS doped with La and Y under in vitro conditions

XRD, EDX and FTIR study of the bioactivity of 60S GLASS doped with La and Y under in vitro conditions

Alginate-Sr/Mg Containing Bioactive Glass Scaffolds: The Characterization of a New 3D Composite for Bone Tissue Engineering

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