Processing of quaternized polysulfones solutions as tool in design of electrospun nanofibers: Microstructural characteristics and antimicrobial activity

Filimon, Anca; Olaru, Niculae; Doroftei, Florica; Coroabă, Adina; Dunca, Simona

doi:10.1016/j.molliq.2021.115664

Cited by 14 publications

(17 citation statements)

References 65 publications

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“…Additionally, according to the data from Table 2 , it can be stated that compared to PSFQ [ 46 ] ( Figures S1 and S2, Supplementary Materials ), phosphonium-functionalized polysulfone exhibits a higher glass transition temperature. This aspect allows us to support the hypothesis, according to which the polymers carrying these groups have different properties from those of other functionalized polysulfones, which is why the interest in the investigation of alternative phosphonic “protogenic” groups has increased [ 47 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

“…Based on previous studies [ 24 , 25 , 46 ], it is well known that some positively charged polymeric materials present antibacterial properties and, as a result of their charge, can kill bacteria or prevent their attachment [ 77 ]. In this context, it is generally accepted that the bactericidal action mechanism of polycationic materials involves destructive interactions with the bacterial cell walls (negatively charged, containing phosphatidylethanolamine as major component) and/or cytoplasmic membranes [ 78 ].…”

Section: Resultsmentioning

confidence: 99%

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Structure-Bioactivity Relationship of the Functionalized Polysulfone with Triethylphosphonium Pendant Groups: Perspective for Biomedical Applications

Dobos¹,

Popa

Rîmbu

et al. 2023

Polymers

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Development of new biomaterials based on polysulfones tailored to act in various biomedical fields represents a promising strategy which provides an opportunity for enhancing the diagnosis, prevention, and treatment of specific illnesses. To meet these requirements, structural modification of the polysulfones is essential. In this context, for design of new materials with long-term stability, enhanced workability, compatibility with biological materials and good antimicrobial activity, the functionalization of chloromethylated polysulfones with triethylphosphonium pendant groups (PSFEtP+) was adopted. The surface chemistry analysis (Fourier transform infrared spectroscopy (FTIR), Energy-dispersive X-ray spectroscopy (EDX)), rheological properties, morphological aspects (Scanning electron microscopy (SEM), polarized light microscopy (POM)), and antimicrobial activity of the synthetized polysulfone were investigated to establish the relationship between its structure and properties, as an important indicator for targeted applications. Based on the obtained features, evaluated by the relationship between the rheological properties and microstructural aspects, and also the response at the biomaterial-bacteria interface, these qualities have been confirmed in their performance, in terms of thermal stability, antimicrobial activity, and also an increase in lifetime. Consequently, derived results constitute the preliminary basis for future tests concerning their functionality as gel matrices in biomedical devices.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Structure-Bioactivity Relationship of the Functionalized Polysulfone with Triethylphosphonium Pendant Groups: Perspective for Biomedical Applications

Dobos¹,

Popa

Rîmbu

et al. 2023

Polymers

Self Cite

View full text Add to dashboard Cite

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“…Gram-positive bacteria have a cell wall made of a thick and rigid peptidoglycan layer (>10 layers) with polymeric teichoic acids and a cytoplasmic membrane. The teichoic acid polymeric chains have a phosphate group that provides a negative charge to bacterial surfaces and serves as a binding site for the divalent cations in the solution [ 144 , 145 , 146 , 147 ]. On the other hand, gram-negative bacteria have a thin cytoplasmic membrane, thin peptidoglycan layer, and lipopolysaccharides, which can reduce the penetration ability of antimicrobial agents ( Figure 2 ) [ 148 , 149 , 150 ].…”

Section: Nanofiber Action Towards Bacteriamentioning

confidence: 99%

Functionalized Antimicrobial Nanofibers: Design Criteria and Recent Advances

Hamdan

Yamin

Hamid

et al. 2021

JFB

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The rise of antibiotic resistance has become a major threat to human health and it is spreading globally. It can cause common infectious diseases to be difficult to treat and leads to higher medical costs and increased mortality. Hence, multifunctional polymeric nanofibers with distinctive structures and unique physiochemical properties have emerged as a neo-tool to target biofilm and overcome deadly bacterial infections. This review emphasizes electrospun nanofibers’ design criteria and properties that can be utilized to enhance their therapeutic activity for antimicrobial therapy. Also, we present recent progress in designing the surface functionalization of antimicrobial nanofibers with non-antibiotic agents for effective antibacterial therapy. Lastly, we discuss the future trends and remaining challenges for polymeric nanofibers.

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“…Reduced microorganism colonization with an implant might be another effective way to enable the immune system to eliminate bacteria, which was found to be capable of resolving the issue of bacterial contamination of surgical implants [26,27]. Previous studies have reported that micro/nano-topographies could prevent implant surfaces from microorganism colonization [28][29][30][31]. Recently, Machado-Paula et al initially generated macro-fibers with special topography surfaces by rotary jet spinning in order to protect bacterial colonization [32].…”

Section: Introductionmentioning

confidence: 99%

Tailoring Nano-Porous Surface of Aligned Electrospun Poly (L-Lactic Acid) Fibers for Nerve Tissue Engineering

Xuan

Xiong

et al. 2021

IJMS

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Despite the existence of many attempts at nerve tissue engineering, there is no ideal strategy to date for effectively treating defective peripheral nerve tissue. In the present study, well-aligned poly (L-lactic acid) (PLLA) nanofibers with varied nano-porous surface structures were designed within different ambient humidity levels using the stable jet electrospinning (SJES) technique. Nanofibers have the capacity to inhibit bacterial adhesion, especially with respect to Staphylococcus aureus (S. aureus). It was noteworthy to find that the large nano-porous fibers were less detrimentally affected by S. aureus than smaller fibers. Large nano-pores furthermore proved more conducive to the proliferation and differentiation of neural stem cells (NSCs), while small nano-pores were more beneficial to NSC migration. Thus, this study concluded that well-aligned fibers with varied nano-porous surface structures could reduce bacterial colonization and enhance cellular responses, which could be used as promising material in tissue engineering, especially for neuro-regeneration.

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Processing of quaternized polysulfones solutions as tool in design of electrospun nanofibers: Microstructural characteristics and antimicrobial activity

Cited by 14 publications

References 65 publications

Structure-Bioactivity Relationship of the Functionalized Polysulfone with Triethylphosphonium Pendant Groups: Perspective for Biomedical Applications

Structure-Bioactivity Relationship of the Functionalized Polysulfone with Triethylphosphonium Pendant Groups: Perspective for Biomedical Applications

Functionalized Antimicrobial Nanofibers: Design Criteria and Recent Advances

Tailoring Nano-Porous Surface of Aligned Electrospun Poly (L-Lactic Acid) Fibers for Nerve Tissue Engineering

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