Processing Speed and Time since Diagnosis Predict Adaptive Functioning Measured with WeeFIM in Pediatric Brain Tumor Survivors

Oprandi, Maria Chiara; Oldrati, Viola; Fave, Morena Delle; Panzeri, Daniele; Gandola, Lorenza; Massimino, Maura; Bardoni, Alessandra; Poggi, Geraldina

doi:10.3390/cancers13194776

Cited by 9 publications

(4 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the difference in age at onset of kidney failure does not fully account for these ndings, as our analysis was adjusted for age. Diminished processing speed has been found to be a predictor of reduced adaptive functioning and daily living skills in some pediatric populations [20], highlighting the importance of monitoring and ongoing support for processing speed (e.g., physical therapy, occupational therapy, and educational supports) for patients who have CAKUT and patients who develop kidney failure at an earlier age.…”

Section: Discussionmentioning

confidence: 99%

Neurocognitive Profile in Pediatric Kidney Transplant Candidates: Effects of Medical and Sociodemographic Factors

Gu,

Anzalone,

Kane-Grade

et al. 2024

Preprint

View full text Add to dashboard Cite

Background We evaluated the effects of kidney failure etiology, dialysis, and sociodemographic factors on the subdomains of intellectual functioning in pediatric kidney transplant candidates. Methods This retrospective study included 78 pediatric kidney transplant candidates who completed a Wechsler Intelligence Scale assessment during pre-transplant neuropsychological evaluation between 1/1/2010 and 10/31/2022. Linear regression models were employed to examine the effects of kidney failure etiology, dialysis status, neighborhood area deprivation, and race on subdomains of intellectual functioning. Results The mean scores of various intellectual functioning domains in pediatric kidney transplant candidates were significantly lower than in the general population (ps <0.001). After adjusting for covariates, patients with congenital anomalies of the kidney and urinary tract had significantly lower processing speed (M=85; 95% CI: 79-91) compared to patients with nephrotic syndrome (M=99; 95% CI: 90-107) and other etiologies (M=84; 95% CI: 78-90) (p=0.003). Patients living in high-level deprivation neighborhoods showed lower working memory performance (M=84, 95% CI: 77-91) than patients living in median-level (M=91, 95% CI: 87-95) and low-level (M=98, 95% CI: 92-104) neighborhood area deprivation (p=0.03). Patients from marginalized racial groups demonstrated lower verbal skills (M=80, 95% CI: 74-87) than White patients (M=92, 95% CI: 88-97) (p=0.02). Additionally, patients receiving dialysis showed higher reasoning skills (M=98, 95% CI: 90-104) than patients without dialysis (M= 90, 95% CI: 86-95) (p=0.04). Conclusions Neurocognitive development in pediatric kidney transplant candidates is associated with medical and sociodemographic factors. Strategies to monitor, treat, and accommodate neurocognitive concerns need to be considered to optimize long-term medical and social outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Neurocognitive Profile in Pediatric Kidney Transplant Candidates: Effects of Medical and Sociodemographic Factors

Gu,

Anzalone,

Kane-Grade

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…We referenced a dataset on patients with CBT [47][48] from May 2021 for an experiment in the Eugenio Medea Scientific Institute in Bosisio Parini, Italy. The original dataset consisted of 78 patients, five of whom we excluded as outliers.…”

Section: Data Descriptionmentioning

confidence: 99%

“…Research ethics and patient consentAll the data in this study are obtained from a public resource in Ref. [47]. The database is publicly available and provided in Ref.…”

mentioning

confidence: 99%

Ensemble learning based functional independence ability estimator for pediatric brain tumor survivors

Lin

Kuo

2022

Health Informatics J

View full text Add to dashboard Cite

A history of brain tumor strongly affects children’s cognitive abilities, performance of daily activities, quality of life, and functional outcomes. In light of the difficulties in cognition, communication, physical skills, and behavior that these patients may encounter, occupational therapists should perform a comprehensive needs-led assessment of their global functioning after recovery. Such an assessment would ensure that the patients receive adequate support and services at school, at home, and in the community. By predicting the functional activity performance of children with a history of brain tumor, clinical workers can determine the progress of their ability recovery and the optimal treatment plan. We selected several features for testing and employed common machine learning models to predict Functional Independence Measure (WeeFIM) scores. The ensemble learning models exhibited stronger predictive performance than did the individual machine learning models. The ensemble learning models effectively predicted WeeFIM scores. Machine learning models can help clinical workers predict the functional assessment scores of patients with childhood brain tumors. This study used machine learning models to predict the WeeFIM scores of patients with childhood brain tumors and to demonstrate that ensemble machine learning models are more suitable for this task than are individual machine learning models.

show abstract

“…[8] Medical concern on HRQOL theme has progressively emerged even in oncological pediatric patients and their parents, due to the potential acute and long-term side effects reported during and after oncological treatments as well as the increase of the survival [7,[9][10][11]. Furthermore, literature on cancer survivors documents numerous and frequent consequences on physical, psychological and relational aspects that may be related either to the disease or to the treatments [12][13][14][15]. Radiotherapy (RT), with or without chemotherapy, is one of the most relevant treatment options for pediatric cancer [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

The Italian Version of the Pediatric Quality of Life Inventory™ (Pedsql™) 3.0 Healthcare Satisfaction Hematology/oncology Module: Reliability and Validity in Radiation Oncology

Marconi

Bartoli

Meldolesi

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Health-related quality of life (HRQOL) measurement has become an important health care outcome even in oncological pediatric scenario. During radiation therapy care path, pediatric patients and their relatives may suffer from emotional and psychosocial distress not only related to cancer diagnosis, but also due to the procedure and the required daily routine. Despite the high prevalence of psychosocial consequences in this setting, instruments that inquire pediatric HRQOL and healthcare satisfaction have rarely been studied in Italy. Purpose of this study was to investigate reliability and linguistic validation of the PedsQL™ healthcare satisfaction Hematology/Oncology module from its original English version to Italian language. Methods Three phases standard procedure of cross-culture adaptation were used to create Italian version of PedsQL™ healthcare satisfaction Hematology/Oncology module. Forward translations and backward translations were performed. Finally, a pilot-testing for understandability of the 'pre-final' version was conducted with parents of children attending our Radiotherapy Center using two methodologies of Cognitive Interviewing (“Thinkaloud Interviews” and “Respondent Debriefing”), in order to obtain the final Italian version of the PedsQL™ healthcare satisfaction Hematology/Oncology module. Results Twenty-five parents (2 father, 23 mothers) were recruited during their children’s radiotherapy treatment and the grammatically and conceptually acceptable pre-final version of the PedsQL™ Healthcare Satisfaction Hematology/Oncology Module was administered. The questionnaire was well understood reflecting its linguistic adaptation. Compliance with questionnaire administration was optimal. All subjects stated that the questions were interesting to express their opinion, most of them reported that all the questions of each section were clearly comprehensible and easy to understand, suggesting minimal changes that were double-checked with back translation. Furthermore, six of them spontaneously asked to complete the questionnaire in order to review the assistance received during radiotherapy. Conclusion Our Italian version of the PedsQL™ 3.0 Healthcare Satisfaction Hematology/Oncology Module seems to be a valid and functional instrument to indagate Healthcare Satisfaction.

show abstract

Processing Speed and Time since Diagnosis Predict Adaptive Functioning Measured with WeeFIM in Pediatric Brain Tumor Survivors

Cited by 9 publications

References 103 publications

Neurocognitive Profile in Pediatric Kidney Transplant Candidates: Effects of Medical and Sociodemographic Factors

Neurocognitive Profile in Pediatric Kidney Transplant Candidates: Effects of Medical and Sociodemographic Factors

Ensemble learning based functional independence ability estimator for pediatric brain tumor survivors

The Italian Version of the Pediatric Quality of Life Inventory™ (Pedsql™) 3.0 Healthcare Satisfaction Hematology/oncology Module: Reliability and Validity in Radiation Oncology

Contact Info

Product

Resources

About