Processing-structure-property relationships of electrospun PLA-PEO membranes reinforced with enzymatic cellulose nanofibers

Ghafari, Robab; Scaffaro, Roberto; Gulino, Emmanuel Fortunato; Re, Giada Lo; Jonoobi, Mehdi

doi:10.1016/j.polymertesting.2019.106182

Cited by 33 publications

(17 citation statements)

References 49 publications

(69 reference statements)

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“…Recently, the study of graphene and its derivatives as a promising material for biomedical application-and particularly for wound dressing-has been considered [6][7][8][9][10]. Graphene is a single layer of sp 2 hybridized carbon atoms creating a hexagonal lattice, and possessing unique properties, i.e., high specific surface area (~2630 m 2 /g), high electron mobility [11,12], thermal conductivity of between 2-5 kW•(m•K) −1 , [13,14] and the highest known Young modulus (~1 TPa) [15,16].…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials

et al. 2020

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Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide (Exf-GO) as a filler. Exf-GO was first obtained by the strong oxidation and exfoliation of graphite. The structural, morphological and mechanical properties of the composites (CMCx/Exf-GO) were evaluated, and the obtained composites were homogenous, transparent and brownish in color. The results confirmed that Exf-GO may be homogeneously dispersed in CMC. It was found that the composite has an inhibitory activity against the Gram-positive Staphylococcus aureus, but not against Gram-negative Pseudomonas aeruginosa. At the same time, it does not exhibit any cytotoxic effect on normal fibroblasts.

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Section: Introductionmentioning

confidence: 99%

Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials

et al. 2020

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“…In the particular case of CNFs production, the enzymatic hydrolysis is commonly followed by a mechanical step of fibrillation, such as homogenization [ 38 , 44 ], microfluidization [ 49 , 50 ], extrusion [ 25 , 51 ], and sonication [ 27 , 52 ], among others. Few studies have also reported no mechanical treatment step after hydrolysis [ 12 , 53 , 54 , 55 ], hence totally relying on the enzymes to produce the nanofibers.…”

Section: Nanocellulose Production By Enzymatic Hydrolysismentioning

confidence: 99%

“…This fact highlights the important role of the composition of the enzymatic mixture on the final yield of extraction, raising the question of whether a complex cellulases cocktail may be the most suitable option in this context. In fact, even though several studies report the use of complex cocktails, such as Cellic CTec [ 2 , 41 , 55 ], the most frequent option refers to the application of monocomponent endoglucanase, such as the Novozym 476 [ 40 , 49 , 50 ], preparations for fibers modification, such as Fibercare R [ 36 , 62 , 74 ] and Cellusoft L [ 75 , 76 ], or other individual EGs [ 45 ].…”

Section: Nanocellulose Production By Enzymatic Hydrolysismentioning

confidence: 99%

Nanocellulose Production: Exploring the Enzymatic Route and Residues of Pulp and Paper Industry

et al. 2020

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Increasing environmental and sustainability concerns, caused by current population growth, has promoted a raising utilization of renewable bio-resources for the production of materials and energy. Recently, nanocellulose (NC) has been receiving great attention due to its many attractive features such as non-toxic nature, biocompatibility, and biodegradability, associated with its mechanical properties and those related to its nanoscale, emerging as a promising material in many sectors, namely packaging, regenerative medicine, and electronics, among others. Nanofibers and nanocrystals, derived from cellulose sources, have been mainly produced by mechanical and chemical treatments; however, the use of cellulases to obtain NC attracted much attention due to their environmentally friendly character. This review presents an overview of general concepts in NC production. Especial emphasis is given to enzymatic hydrolysis processes using cellulases and the utilization of pulp and paper industry residues. Integrated process for the production of NC and other high-value products through enzymatic hydrolysis is also approached. Major challenges found in this context are discussed along with its properties, potential application, and future perspectives of the use of enzymatic hydrolysis as a pretreatment in the scale-up of NC production.

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“…In recent years, there has been growing attention to fabricate porous structures for wound dressing applications based on natural and synthetic polymers via different techniques. Polylactide (PLA) is one of the biopolymers that has been widely used in wound dressing applications due to its biocompatibility, biodegradability, good mechanical durability, and non-toxicity to the human body [ 5 , 6 ]. However, PLA is highly hydrophobic, which severely restricts its application in the field of wound dressing due to the limitation of water uptake capacity.…”

Section: Introductionmentioning

confidence: 99%

Polylactide/Polyvinylalcohol-Based Porous Bioscaffold Loaded with Gentamicin for Wound Dressing Applications

et al. 2021

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: This study explores the feasibility of modifying the surface liquid spraying method to prepare porous bioscaffolds intended for wound dressing applications. For this purpose, gentamicin sulfate was loaded into polylactide-polyvinyl alcohol bioscaffolds as a highly soluble (hygroscopic) model drug for in vitro release study. Moreover, the influence of inorganic salts including NaCl (10 g/L) and KMnO4 (0.4 mg/L), and post-thermal treatment (T) (80 °C for 2 min) on the properties of the bioscaffolds were studied. The bioscaffolds were characterized by scanning electron microscopy, Fourier Transform infrared spectroscopy, and differential scanning calorimetry. In addition, other properties including porosity, swelling degree, water vapor transmission rate, entrapment efficiency, and the release of gentamicin sulfate were investigated. Results showed that high concentrations of NaCl (10 g/L) in the aqueous phase led to an increase of around 68% in the initial burst release due to the increase in porosity. In fact, porosity increased from 68.1 ± 1.2 to 94.1 ± 1.5. Moreover, the thermal treatment of the Polylactide-polyvinyl alcohol/NaCl (PLA-PVA/NaCl) bioscaffolds above glass transition temperature (Tg) reduced the initial burst release by approximately 11% and prolonged the release of the drug. These results suggest that thermal treatment of polymer above Tg can be an efficient approach for a sustained release.

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Processing-structure-property relationships of electrospun PLA-PEO membranes reinforced with enzymatic cellulose nanofibers

Cited by 33 publications

References 49 publications

Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials

Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials

Nanocellulose Production: Exploring the Enzymatic Route and Residues of Pulp and Paper Industry

Polylactide/Polyvinylalcohol-Based Porous Bioscaffold Loaded with Gentamicin for Wound Dressing Applications

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