Due to its multiple advantages in industrial and grid-connected applications, Multi-Level Inverters (MLIs) have increased in popularity in recent years. To improve the efficiency of a grid-connected PV system's integrated multi-level inverter fractional order PI (FOPI) controllers are used to describe the control process. The control system is made up of three control loops based on FOPI controllers: one for controlling the intermediate circuit voltage (Vdc) and the other two for controlling the direct and quadratic currents (Id, Iq) supplied by the multilevel inverter. The proposed controller parameters (K p , K I , λ)must be selected in order to increase the efficiency of the multi-level inverter while decreasing the total harmonic distortion (THD) of the output current of the inverter as well as voltage. For this we used three meta-heuristic algorithms (PSO, ABC, GWO). The performance of the three controllers PSO-FOPI, ABC-FOPI and GWO-FOPI controller is compared. The findings showed that GWO-FOPI performs better than the other PSO-FOPI and ABC-FOPI in accuracy and total harmonic distortion THD term. The simulation will be conducted using Matlab/Simulink.