Procyanidin A2, an anti-diabetic condensed tannin extracted from <i>Wendlandia glabrata</i>, reduces elevated G-6-Pase and mRNA levels in diabetic mice and increases glucose uptake in CC1 hepatocytes and C1C12 myoblast cells

Sheikh, Yunus; Chanu, Maibam Beebina; Mondal, Gopinath; Manna, Prasenjit; Chattoraj, Asamanja; Deka, Dibakar Chandra; Talukdar, Narayan Chandra; Borah, Jagat C.

doi:10.1039/c9ra02397f

Cited by 20 publications

(26 citation statements)

References 33 publications

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“…Procyanidin A2 (Fig. 3 ; Table 2 ), isolated from the shoots of Wendlandia glabrata , inhibited alpha-glucosidase enzyme with a remarkably low IC 50 value of 0.47 μM compared to 586.6 μM for acarbose (Sheikh et al 2019 ). It is an A-type dimeric form of procyanidin.…”

Section: Plant Secondary Metabolites As Alpha-glucosidase Inhibitorsmentioning

confidence: 99%

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

et al. 2021

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Diabetes mellitus is a multifactorial global health disorder that is rising at an alarming rate. Cardiovascular diseases, kidney damage and neuropathy are the main cause of high mortality rates among individuals with diabetes. One effective therapeutic approach for controlling hyperglycemia associated with type-2 diabetes is to target alpha-amylase and alpha-glucosidase, enzymes that catalyzes starch hydrolysis in the intestine. At present, approved inhibitors for these enzymes are restricted to acarbose, miglitol and voglibose. Although these inhibitors retard glucose absorption, undesirable gastrointestinal side effects impede their application. Therefore, research efforts continue to seek novel inhibitors with improved efficacy and minimal side effects. Natural products of plant origin have been a valuable source of therapeutic agents with lesser toxicity and side effects. The anti-diabetic potential through alpha-glucosidase inhibition of plant-derived molecules are summarized in this review. Eight molecules (Taxumariene F, Akebonoic acid, Morusin, Rhaponticin, Procyanidin A2, Alaternin, Mulberrofuran K and Psoralidin) were selected as promising drug candidates and their pharmacokinetic properties and toxicity were discussed where available. Supplementary Information The online version contains supplementary material available at 10.1007/s11101-021-09773-1.

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Section: Plant Secondary Metabolites As Alpha-glucosidase Inhibitorsmentioning

confidence: 99%

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

et al. 2021

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“…The observed data matches with the already reported condensed tannin Procyanidin A2 (Spectroscopic data as presented in S3, ESI†). 11…”

Section: Resultsmentioning

confidence: 99%

“…Glucose uptake assay was performed according to the protocol previously standardized by Yunus Seikh et al 11 with crude extract, fractions, and isolated molecules. All the extracts, fractions, and isolated molecules (free of organic solvent) were dissolved in 1× phosphate buffered saline (PBS) to make the treatment solution.…”

Section: Methodsmentioning

confidence: 99%

“…9,10 Wendlandia glabrata DC is traditionally being used as a dietary supplement by the indigenous communities in North East India for the treatment of obesity, diabetes, and related metabolic syndrome. 11 It has also been reported to be an expectorant and beneficial in stomach ailments. 12 Our previous study has revealed the antihyperglycemic potential of procyanidin A2 isolated from the W. glabrata.…”

Section: Introductionmentioning

confidence: 99%

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Iridoid glycoside isolated from Wendlandia glabrata and the role of its enriched fraction in regulating AMPK/PEPCK/G6Pase signaling pathway of hepatic gluconeogenesis

et al. 2022

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“…Similarly, PCA exhibits insulin-mimicking properties by activating INSR signaling, reversing INS-1 serine phosphorylation, and activating PI3K/AKT and AMPK signaling pathways, and subsequently increasing GLUT4 translocation and glu cose uptake in adipocytes [24]. Moreover, PCA has been shown to reduce glucose-6-phos phatase expression and activity and to promote glucose uptake in hepatocytes and my oblasts [25]. Hence, PCA seems to be a possible candidate in preventing metabolic disor ders associated with lipid and glucose metabolism dysregulations and insulin resistance…”

Section: Protocatechuic Acid Is the Main Contributor To Glucose And L...mentioning

confidence: 99%

Role of the Phytochemicals from the Cocoa Shell on the Prevention of Metabolic Syndrome by an Integrated Network Pharmacology Analysis

Rebollo‐Hernanz

Cañas

Braojos

et al. 2021

The 1st International Electronic Conference on Biomedicine

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The metabolic syndrome is a cluster of conditions that occur together, increasing the risk of chronic diseases such as obesity, type II diabetes, or cardiovascular disease. Nutritional interventions improving inflammation, bioenergetics, and oxidative stress are proposed as effective tools in preventing metabolic syndrome. The cocoa shell is a by-product generated in large amounts during cocoa production. This by-product contains alkaloids and phenolic compounds as main compounds and has been investigated as an anti-obesity and anti-diabetic agent. Here, we used network pharmacology to explore the potential mechanism of the phytochemicals from the cocoa shell. We searched the cocoa shell’s phytochemical composition; then, oral bioavailability and drug-likeness were screened. We predicted the targets for the phytochemicals found in this by-product and used different databases to search for compound–protein and compound–gene interactions, and then protein–protein interaction networks were constructed. Moreover, pathway enrichment analysis was performed, and biological processes and signaling pathways were identified and illustrated through bioinformatics analyses. Theobromine, caffeine, procyanidin B2, (−)-epicatechin, (+)-catechin, and protocatechuic acid were identified in the cocoa shell as main components. Those phytochemicals were associated with inflammation (TNF-α, NF-κB, JNK)-, oxidative stress (CAT, SOD)-, obesity (adiponectin, leptin, FASN, PPAR-α)-, and diabetes (insulin, AKT)-related pathways. Results demonstrated that cocoa shell phytochemicals could modulate multiple biological processes and signaling pathways in a multimechanistic manner. Hence, cocoa shell consumption could support the nutritional prevention of metabolic syndrome. Future in vivo and clinical investigations will be needed to validate this potential nutraceutical and healthy ingredient’s effects and mechanisms.

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Procyanidin A2, an anti-diabetic condensed tannin extracted from Wendlandia glabrata, reduces elevated G-6-Pase and mRNA levels in diabetic mice and increases glucose uptake in CC1 hepatocytes and C1C12 myoblast cells

Abstract: Wendlandia glabrata and procyanidin A2 isolated thereof are exhibited significant anti-diabetic effect.

Cited by 20 publications

References 33 publications

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes

Iridoid glycoside isolated from Wendlandia glabrata and the role of its enriched fraction in regulating AMPK/PEPCK/G6Pase signaling pathway of hepatic gluconeogenesis

Role of the Phytochemicals from the Cocoa Shell on the Prevention of Metabolic Syndrome by an Integrated Network Pharmacology Analysis

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