“…Procyanidins have been suggested to have strong antioxidative activity [18,19] and various physiological functions [20][21][22][23][24], as demonstrated with in vitro molecular investigations and in vivo animal studies. Apples are widely consumed throughout the world and are an important source of procyanidins in the human diet [17,25]. Apples contain different structural subclasses, including phenolic acids and flavonoids, comprising six major classes: phenolcarboxylic acids (e.g., chlorogenic acid), anthocyanins (e.g., cyanidin glycosides), flavonols (e.g., quercetin glycosides), dihydrochalcones (e.g., phloridzin), flavan-3-ols (e.g., catechin), and procyanidins (e.g., procyanidin B2) ( Figure S1).…”