Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway

Liu, Yao; Sun, Ruifang; Lin, Xiaoping; Wu, Lei; Chen, Hengying; Shen, Siwen; Li, Yan; Wei, Yuanhuan; Deng, Guifang

doi:10.1016/j.biopha.2022.113078

Cited by 22 publications

(17 citation statements)

References 44 publications

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“…Procyanidins lowered insulin resistance in mice with GDM and in postpartum mice through the NF-κB–NLRP3 pathway. 110 Previous data revealed that puerarin exerted preventive effects in liver, pancreas, and adipose tissues against GDM-induced pathological changes and effectively ameliorated glucose- and lipid-metabolism disorders, insulin resistance, and inflammation in rats with GDM, which may be closely related to downregulation of the downstream TLR4–MyD88–NF-κB inflammatory pathway. 115 Lappas et al showed that dietary polyphenols (curcumin, naringenin, and apigenin) reduced infection and inflammation-induced pro-labor mediators in cultured human pregnancy-related tissues, such as the placenta, fetal membrane, and myometrium, via the NF-κB pathway.…”

Section: Effects Of Polyphenols On Mothers With Maternal Diabetes And...mentioning

confidence: 97%

Section: Effects Of Polyphenols On Mothers With Maternal Diabetes And...mentioning

confidence: 99%

“…Previous data showed that intervention with procyanidins (27.8 mg kg −1 ) increased glucose metabolism and reduced the secretion of inflammatory factors (TNF-α, IL-6, IL-17, C-reactive protein) in mice with high-fat and high-sucrose diet-induced GDM. 110 Protocatechuic acid is a major anthocyanin-rich metabolite in plant foods with insulin-mimetic activity. VAT samples were obtained from pregnant women with GDM or normal glucose tolerance (NGT) during delivery.…”

Section: Reviewmentioning

confidence: 99%

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Effects of dietary polyphenols on maternal and fetal outcomes in maternal diabetes

Zhao,

Chang,

Cong

et al. 2023

Food Funct.

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Section: Effects Of Polyphenols On Mothers With Maternal Diabetes And...mentioning

confidence: 97%

Section: Effects Of Polyphenols On Mothers With Maternal Diabetes And...mentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

See 1 more Smart Citation

Effects of dietary polyphenols on maternal and fetal outcomes in maternal diabetes

Zhao,

Chang,

Cong

et al. 2023

Food Funct.

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“…Procyanidin B1 is also a promising liver cancer antitumor drug [ 473 ] (Na et al, 2020). Procyanidins increase the glycometabolism and decrease the secretion of inflammatory factors of postpartum mice with gestational diabetes mellitus (GDM) [ 474 ].…”

Section: The Health Benefits Of Condensed Tannins or Proanthocyanidin...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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“…Insulin resistance is reduced by macrophage HIF-2, which prevents the NLRP3 inflammasome from being activated by fatty acid oxidation. 89 In the same study, mice were shielded by the force with PPA. This study may provide fresh perspectives on how PB2 inhibits PPA catalysis and valuable information on PB2 dietary recommendations for the management of type 2 DM.…”

Section: Dm Pancreasmentioning

confidence: 99%

Procyanidins: A promising anti‐diabetic agent with potential benefits on glucose metabolism and diabetes complications

Qaed,

Almoiliqy,

Al‐Hamyari

et al. 2023

Wound Repair Regeneration

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Diabetes mellitus (DM) is a complex disease with alarming worldwide health implications and high mortality rates, largely due to its complications such as cardiovascular disease, nephropathy, neuropathy, and retinopathy. Recent research has shown that Procyanidins (PC), a type of flavonoid, have strong antioxidant and free radical elimination effects, and may be useful in improving glucose metabolism, enhancing pancreatic islet cell activity, and decreasing the prevalence of DM complications. This review article presents a systematic search for peer‐reviewed articles on the use of PC in the treatment of DM, without any language restrictions. The article also discusses the potential for PC to sensitize DM medications and improve their efficacy. Recent in vivo and in vitro studies have demonstrated promising results in improving the biological activity and bioavailability of PC for the treatment of DM. The article concludes by highlighting the potential for novel materials and targeted drug delivery methods to enhance the pharmacokinetics and bioactivity of PC, leading to the creation of safer and more effective anti‐DM medications in the future.This article is protected by copyright. All rights reserved.

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Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway

Cited by 22 publications

References 44 publications

Effects of dietary polyphenols on maternal and fetal outcomes in maternal diabetes

Effects of dietary polyphenols on maternal and fetal outcomes in maternal diabetes

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Procyanidins: A promising anti‐diabetic agent with potential benefits on glucose metabolism and diabetes complications

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