Prodigiosin-Conjugated Aptamer for Attachment to the Surface of Brain Cancer Cells Mediated by Glutamate Receptor

Ayatollahi, M. Hossein; Ayatollahi, Gelayol; Rashidi, Mohsen; Hekmatimoghaddam, Seyedhossein; Mosshafi, Mohammadhassan; Jebali, Ali; Iman, Maryam; Sardo, Hossein Shahdadi

doi:10.1016/j.colcom.2018.03.006

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…A new strategy in vaccine design is to target B-cells by derivatizing the nanoparticle carrier with TLR ligands [ 53 ]. The surface manipulation [ 54 , 55 ] and the use of detector molecules such as aptamers [ 56 ] are examples of targeting. Of course, each method has its advantages and limitations [ 57 ].…”

Section: Other Nanoparticlesmentioning

confidence: 99%

The Use of Nanobiotechnology in Immunology and Vaccination

2021

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Nanotechnology uses the unique properties of nanostructures with a size of 1 to 200 nanometers. Different nanoparticles have shown great promise for the production of new vaccines and drugs. Nanostructures can be used to deliver immunological compounds more effectively than microstructures to target sites. Different nanostructures can be applied to form a new generation of vaccines, adjuvants, and immune system drugs. The goal of nanotechnology is to better respond to a wide range of infectious and non-infectious diseases.

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Section: Other Nanoparticlesmentioning

confidence: 99%

The Use of Nanobiotechnology in Immunology and Vaccination

2021

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“…It was observed that aptamers 8, 10, 11, 23, and 69 have the ability to target epitopes on all brain cancer cells with high affinity and low Δ INME. In addition, among these, the aptamer 10 was adsorbed by brain cancer cells at high levels and its adsorption by normal cells was dramatically low [136].…”

Section: Diagnosismentioning

confidence: 99%

Aptamer Applications in Neuroscience

Ozturk¹,

Nilsen-Hamilton²,

İlgü³

2021

Preprint

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Being the predominant cause of disability, neurological diseases have received much attention from the global health community. Over a billion people suffer from one of the following neurological disorders: dementia, epilepsy, stroke, migraine, meningitis, Alzheimer's disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s disease, prion dis-ease, or brain tumors. Diagnosis and treatment options are limited for many of these diseases. Aptamers, being small and non-immunogenic nucleic acid molecules that are easy to chemically modify, offer potential diagnostic and theranostic applications to meet these needs. This review covers pioneer studies to apply aptamers, which show promise for future diagnostics and treatments of neurological disorders that pose increasingly dire worldwide health challenges.

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“…Lastly, MD simulation under canonical (NVT) ensemble was used to interact with each epitope of the aptamer‐drug conjugation at 310 K for 50 ns duration. The result showed that the simulated aptamer‐drug conjugate possessed efficient binding property with U‐87 MG brain cancer cells, compared to normal SK‐N‐MC brain cells . DNA aptamer conjugated liposomal system was also designed using CHARMM to target doxorubicin (DOX)‐resistant MCF7/ADR breast cancer cells .…”

Section: Molecular Dynamics Simulations Of Dna Aptamer Binding For Tamentioning

confidence: 99%

Advancing Aptamers as Molecular Probes for Cancer Theranostic Applications—The Role of Molecular Dynamics Simulation

Jeevanandam

Tan

Danquah

et al. 2020

Biotechnology Journal

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Theranostics cover emerging technologies for cell biomarking for disease diagnosis and targeted introduction of drug ingredients to specific malignant sites. Theranostics development has become a significant biomedical research endeavor for effective diagnosis and treatment of diseases, especially cancer. An efficient biomarking and targeted delivery strategy for theranostic applications requires effective molecular coupling of binding ligands with high affinities to specific receptors on the cancer cell surface. Bioaffinity offers a unique mechanism to bind specific target and receptor molecules from a range of non‐targets. The binding efficacy depends on the specificity of the affinity ligand toward the target molecule even at low concentrations. Aptamers are fragments of genetic materials, peptides, or oligonucleotides which possess enhanced specificity in targeting desired cell surface receptor molecules. Aptamer–target binding results from several inter‐molecular interactions including hydrogen bond formation, aromatic stacking of flat moieties, hydrophobic interaction, electrostatic, and van der Waals interactions. Advancements in Systematic Evolution of Ligands by Exponential Enrichment (SELEX) assay has created the opportunity to artificially generate aptamers that specifically bind to desired cancer and tumor surface receptors with high affinities. This article discusses the potential application of molecular dynamics (MD) simulation to advance aptamer‐mediated receptor targeting in targeted cancer therapy. MD simulation offers real‐time analysis of the molecular drivers of the aptamer‐receptor binding and generate optimal receptor binding conditions for theranostic applications. The article also provides an overview of different cancer types with focus on receptor biomarking and targeted treatment approaches, conventional molecular probes, and aptamers that have been explored for cancer cells targeting.

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Prodigiosin-Conjugated Aptamer for Attachment to the Surface of Brain Cancer Cells Mediated by Glutamate Receptor

Cited by 8 publications

References 17 publications

The Use of Nanobiotechnology in Immunology and Vaccination

The Use of Nanobiotechnology in Immunology and Vaccination

Aptamer Applications in Neuroscience

Advancing Aptamers as Molecular Probes for Cancer Theranostic Applications—The Role of Molecular Dynamics Simulation

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