Prodromal symptoms in knee osteoarthritis: a nested case–control study using data from the Osteoarthritis Initiative

Case, Rebecca; Thomas, Elaine; Clarke, E.; Peat, George

doi:10.1016/j.joca.2014.12.026

Cited by 36 publications

(39 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings complement prior studies indicating pain precedes radiographic disease in those with accelerated or common KOA [6,9]. Prodromal symptoms may start 2 or 3 years before incident radiographic KOA [9], peak at one year before the onset of incident radiographic KOA, and then stabilize [8].…”

Section: Discussionsupporting

confidence: 87%

“…Prodromal symptoms may start 2 or 3 years before incident radiographic KOA [9], peak at one year before the onset of incident radiographic KOA, and then stabilize [8]. Many adults will report swelling and pain when walking one year before incident radiographic KOA [9]. Our findings agreed with these observations and expanded upon them by demonstrating that adults who develop accelerated KOA report more frequent knee swelling than those who develop common KOA.…”

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

“…We selected the visit before people presented with radiographic evidence for accelerated or common KOA because it is when these individuals are most likely to report greater knee pain severity [6,8,9]. Specifically, people who develop incident KOA start reporting greater knee pain 2 to 3 years before developing radiographic KOA [9], symptoms peak the year before incident radiographic KOA, and then stabilize or diminish in severity after the onset of radiographic disease [6,8,9]. It would be informative to understand the symptoms among people who develop accelerated KOA before they develop advance-stage disease.…”

Section: Methodsmentioning

confidence: 99%

“…Individuals with incident accelerated KOA report greater difficulty with activities of daily living and greater knee pain than those with incident common KOA [6]. Additionally, adults with incident KOA, especially those with accelerated KOA, are more likely to report greater knee symptoms the year before they develop radiographic evidence of KOA [6,8,9]. …”

mentioning

confidence: 99%

See 4 more Smart Citations

Knee symptoms among adults at risk for accelerated knee osteoarthritis: data from the Osteoarthritis Initiative

Davis

Eaton

et al. 2017

Clin Rheumatol

View full text Add to dashboard Cite

Objective To examine if adults who develop accelerated knee osteoarthritis (KOA) have greater knee symptoms with certain activities than those with or without incident common KOA. Methods We conducted a case-control study using data from baseline and the first 4 annual visits of the Osteoarthritis Initiative. Participants had no radiographic KOA at baseline (Kellgren-Lawrence [KL] <2). We classified 3 groups: 1) accelerated KOA: ≥1 knee developed advance-stage KOA (KL=3 or 4) within 48 months, 2) common KOA: ≥1 knee increased in radiographic severity (excluding those with accelerated KOA), and 3) No KOA: no change in radiographic severity by 48-months. We focused on individual items from the WOMAC pain/function subscales and KOOS pain/symptoms subscales. The index visit was a year before a person met the definition for accelerated, common, or no KOA. To examine group difference in knee symptoms we used ordinal logistic regression models for each symptom. Results are reported as odds ratios (OR) and 95% confidence intervals (CI). Results Individuals who developed accelerated KOA were more likely to report greater difficulty with lying down (OR=2.10, 95% CI=1.04 to 4.25), pain with straightening the knee fully (OR=2.04, 95% CI=1.08, 3.85), and pain walking (OR=2.49, 95% CI=1.38, 4.84) than adults who developed common KOA. Conclusion Individuals who develop accelerated KOA report greater symptoms with certain activities than those with common KOA. Our results may help identify individuals at risk for accelerated KOA or with early-stage accelerated KOA.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Knee symptoms among adults at risk for accelerated knee osteoarthritis: data from the Osteoarthritis Initiative

Davis

Eaton

et al. 2017

Clin Rheumatol

View full text Add to dashboard Cite

show abstract

Prevalence of Early Knee Osteoarthritis Illness Among Various Patient‐Reported Classification Criteria After Anterior Cruciate Ligament Reconstruction

Harkey

Baez

Lewis

et al. 2022

Arthritis Care & Research

View full text Add to dashboard Cite

Objective. To compare the prevalence of participants meeting different patient-reported criteria for early osteoarthritis (OA) illness after anterior cruciate ligament reconstruction (ACLR).Methods. Participants completed the Knee Injury and Osteoarthritis Outcomes Score (KOOS) at a single time point 5.0-7.9 months post-ACLR. We used established KOOS subscale criteria (i.e., Luyten original and Englund original) to define patient-reported early OA illness. A two-by-two contingency table and McNemar's test were used to compare the prevalence of participants who met the Luyten original versus Englund original KOOS criteria for early OA illness. These analyses were repeated using KOOS subscale thresholds based on established population-specific patient acceptable symptom state (PASS) within the Luyten and Englund KOOS criteria (i.e., Luyten PASS and Englund PASS).Results. A greater prevalence of participants with ACLR met the Luyten original criteria (n = 165 [54%]) compared to those who met the Englund original criteria (n = 128 [42%]; χ 2 = 19.3, P < 0.001]). When using the KOOS subscale PASS as thresholds, a significantly greater prevalence of participants with ACLR met the Luyten PASS criteria (n = 133 [43%]) compared to those who met the Englund PASS criteria (n = 85 [28%]; χ 2 = 48.0, P < 0.001). When combining the Luyten and Englund KOOS criteria and using the original/PASS subscale thresholds, respectively, 40%/57% of participants met neither, 24%/15% met only 1, and 36%/28% met both KOOS criteria.Conclusion. Regardless of the classification criteria used to define early OA illness, it is concerning that 28-54% of patients report considerable symptoms ~6 months post-ACLR. Our findings will improve the classification criteria to define early OA illness, which may raise awareness for the need of population-specific criteria.symptom state [PASS] question) 1 and 2 years post-ACLR (mean AE SD age 29.7 AE 11.5 years) (7). Being able to reliably identify

show abstract

Adults With Incident Accelerated Knee Osteoarthritis Are More Likely to Use Pharmacological Treatment Options and Receive Arthroscopic Knee Surgery: Data From the Osteoarthritis Initiative

Davis

Harkey

Liu

et al. 2019

ACR Open Rheumatology

View full text Add to dashboard Cite

ObjectiveTo determine if people with incident accelerated knee osteoarthritis (AKOA) were more likely to receive a pharmacological treatment or arthroscopic knee surgery than those with typical knee osteoarthritis (KOA) or no KOA.MethodsWe conducted a nested cohort study using data from baseline and the first 8 years of the Osteoarthritis Initiative. Eligible participants had no radiographic KOA at baseline (Kellgren‐Lawrence [KL] < 2). We classified three groups using KL grades: 1) AKOA: knee progressed to advanced‐stage KOA (KL 3/4) in 4 years or less, 2) typical KOA: knee increased in KL grade by 8 years (excluding AKOA), and 3) No KOA: no change in KL grade by 8 years. The outcome was self‐reported arthroscopic knee surgery or a pharmacological treatment option: nonsteroidal anti‐inflammatory drugs (NSAIDs), hyaluronic acid injections, intra‐articular corticosteroid injections, or prescription analgesics. Between‐group differences in therapeutic use were evaluated with Chi‐square tests.ResultsAdults who developed AKOA (n = 92) were more likely to report arthroscopic knee surgery (AKOA: 32%, KOA [n = 380]: 8%, no KOA [n = 875]: 3%; P < 0.001), hyaluronic acid injections (AKOA: 10%, KOA: 4%, no KOA: 1%; P < 0.001), intra‐articular corticosteroid injections (AKOA: 30%, KOA: 7%, no KOA: 4%; P < 0.001), and NSAID use (over the counter: AKOA: 65%, KOA: 48%, and no KOA: 46%; P = 0.003; prescription: AKOA: 61%, KOA: 43%, no KOA: 41%; P = 0.002).ConclusionAdults with AKOA are more likely to receive pharmacological treatment or arthroscopic knee surgery than their peers. Adults with AKOA are an important patient population that is understudied in clinical research despite their use of greater health care resources.

show abstract

Prodromal symptoms in knee osteoarthritis: a nested case–control study using data from the Osteoarthritis Initiative

Cited by 36 publications

References 37 publications

Knee symptoms among adults at risk for accelerated knee osteoarthritis: data from the Osteoarthritis Initiative

Knee symptoms among adults at risk for accelerated knee osteoarthritis: data from the Osteoarthritis Initiative

Prevalence of Early Knee Osteoarthritis Illness Among Various Patient‐Reported Classification Criteria After Anterior Cruciate Ligament Reconstruction

Adults With Incident Accelerated Knee Osteoarthritis Are More Likely to Use Pharmacological Treatment Options and Receive Arthroscopic Knee Surgery: Data From the Osteoarthritis Initiative

Contact Info

Product

Resources

About