Prodromal symptoms in knee osteoarthritis: a nested case-control study using data from the osteoarthritis initiative

Recomendaciones sobre diagnóstico, prevención y tratamiento farmacológico y no farmacológico de la osteoartritis (OA) de rodilla

“…1,15 Estudios de casos y controles han encontrado como síntoma prodrómico de la OA de rodilla el dolor para realizar ciertas actividades (como subir escaleras) que se puede presentar desde 3 años antes del diagnóstico radiológico. 16 Con frecuencia no hay una fuerte relación entre los cambios radiológicos y los síntomas de OA. De esta manera mínimos cambios radiográficos pueden estar asociados con mucho dolor, o cambios estructurales importantes de las articulaciones, a síntomas mínimos.…”

Association of osteoarthritis risk factors with knee and hip pain in a population-based sample of 2424 30–59 year olds in Denmark: a cross-sectional analysis.

“…Joint pain is a cardinal symptom of OA, which is often present before structural changes are visible on radiographs [15]. Given the strong link between persistent knee/hip pain and later development of OA, younger patients with knee and hip pain may serve a useful model to study the potential presence of OA risk factors earlier in life [11,16].…”

In whom and when to look for causal pathways of osteoarthritis of the knee

“…This finding is line with the result that pain using stairs is among the first prodromal symptoms in knee OA. However, Case et al 1 determined which symptoms precede the development of radiographic knee OA. The other study 2 just looked at which symptoms appear first, without relating symptoms to subsequent radiographic knee OA.…”