Prodrug Polymeric Nanoconjugates Encapsulating Gold Nanoparticles for Enhanced X‐Ray Radiation Therapy in Breast Cancer

Abstract

An optimal radiosensitizer with improved tumor retention has an important effect on tumor radiation therapy. Herein, gold nanoparticles (Au NPs) and drug‐containing, mPEG‐conjugated CUR (mPEG‐CUR), self‐assembled NPs (mPEG‐CUR@Au) are developed and evaluated as a drug carrier and radiosensitizer in a breast cancer mice model. As a result, cancer therapy efficacy is improved significantly by applying all‐in‐one NPs to achieve synchronous chemoradiotherapy, as evidenced by studies evaluating cell viability, proliferation, and ROS production. In vivo anticancer experiments show that the mPEG‐CUR@Au system improves the radiation sensitivity of 4T1 mammary carcinoma and completely abrogates breast cancer.

Recent advances in aqueous virus removal technologies

“…Over the past 20 years, membrane technology has been one of the emerging technologies of wastewater treatment, almost always in the center of attention of environmentalists ( Liu et al, 2022a , 2022b ). Materials used in this technology can be mainly grouped in ceramic and polymeric membranes, each of which has its features such as durability, chemical, mechanical and thermal stability, resistance against bacteria, back flushing ability, and cleaning and sterilization easiness ( Huang et al, 2021 ; Nosrati et al, 2022 ; Xu et al, 2022 ). However, there are still challenges associated with membrane technology, especially in conjunction with the cost of optimization and fabrication, selectivity and antifouling properties.…”

“…Thus, a criterion, called replacement frequency, seems to be really critical for this kind of advanced treatment ( Torii et al, 2019a ; Saadati et al, 2021 ). The advances in nanotechnology have stirred the interest in the development of nanocellulose-, nanochitin- and generally biodegradable polymer-based virus removal filters focusing mainly on the adsorptive type filters acting via electrostatic interactions rather than size exclusion ( Hamed et al, 2016 ; Nosrati et al, 2022 ; Shokri et al, 2022 ).…”

CaZnO-based nanoghosts for the detection of ssDNA, pCRISPR and recombinant SARS-CoV-2 spike antigen and targeted delivery of doxorubicin

“…The convergence between chemistry, nanoscience, and biotechnology leads to the developing of new methods/technologies for advanced generations ( Akça et al, 2021 ; Karaman, 2021 , 2022 ; Deng et al, 2022 ). These technologies are based on the innovative findings of the scientists based on their fundamental knowledge; however, sometimes, these innovative findings lead to unwanted effects with negative impacts ( Liu et al, 2022 ; Nosrati et al, 2022 ; Shokri et al, 2022 ). One of the unwanted effects with negative implications on biomedical engineering science is the cytotoxicity of the developed new (nano)materials.…”

MIL-125-based nanocarrier decorated with Palladium complex for targeted drug delivery

“…These features helped scientists develop a more optimized carrier to enhance the loading and improve the drug release. The carrier has some characteristics, and the most important of them is the size 13 – 15 . If the particle size is < 40 nm, the penetration rate will be so fast because it can easily pass through the endothelial cells, and if it is > 300 nm, the retention time in the cell will be longer and more effective 16 – 19 .…”