Producing ultra-thin silica coatings on iron-oxide nanoparticles to improve their surface reactivity

Kralj, Slavko; Makovec, Darko; Čampelj, Stanislav; Drofenik, Miha

doi:10.1016/j.jmmm.2009.12.038

Cited by 115 publications

(94 citation statements)

References 15 publications

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“…The Fe3O4 (magnetite) and -Fe2O3 (maghemite) are favoured for use because their biocompatibility has already been confirmed [38]. In this work, the IONPs used are -Fe2O3 (maghemite) and are coated with a silica layer [39], and are termed silica-coated iron oxide nanoparticles (SiO2-coated IONPs).…”

Section: Iron Oxide Nanoparticles (Ionps) and Their Toxicitymentioning

confidence: 99%

Sulphur-Containing Compounds as a Response in Sea Urchins Exposed to Alkylated Silicon Nanocrystals and SiO<sub>2</sub>-Coated Iron Oxide Nanoparticles

Šiller

Piticharoenphun

Lemloh

et al. 2016

KEM

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2016) 'Sulphur-containing compounds as a response in sea urchins exposed to alkylated silicon nanocrystals and SiO2-coated iron oxide nanoparticles.', Key engineering materials., 672 . pp. 312-327. Further information on publisher's website:http://dx.doi.org/10.4028/www.scientic.net/KEM.672.312Publisher's copyright statement:Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. Abstract. We report the effects of exposure to alkylated silicon nanocrystals ('alkyl-SiNCs' at concentration ~ 7.2 mg/L) and -Fe2O3 nanoparticles coated with ultra-thin silica ('SiO2-coated IONPs' at concentration ~ 150 mg/L) on sea urchins Paracentrotus lividus and Arbacia lixula, respectively, studied with X-ray fluorescence (XRF) and Fourier transform infrared (FTIR) spectroscpoies using excitation from a synchrotron light source. A remarkably low mortality and low incidence of skeletal deformation is observed for exposure to both types of nanoparticles studied, despite the high concentrations employed in this work. XRF mapping demonstrates that both types of nanoparticle are found to agglomerate in the body of the sea urchins. FTIR spectra indicates that alkyl-SiNCs remain intact after ingestion and corresponding XRF maps show increased an oxygen throughout the organisms, possibly related to oxidation products arising from reactive oxygen species generated in the presence of the nanoparticles. Exposure to SiO2-coated IONPs is found to produce sulphur-containing species, which may be the result of a biological response in order to reduce the toxicity of the nanomaterial.

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Section: Iron Oxide Nanoparticles (Ionps) and Their Toxicitymentioning

confidence: 99%

Sulphur-Containing Compounds as a Response in Sea Urchins Exposed to Alkylated Silicon Nanocrystals and SiO<sub>2</sub>-Coated Iron Oxide Nanoparticles

Šiller

Piticharoenphun

Lemloh

et al. 2016

KEM

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“…The use of shell of silica onto the surface of magnetic nanoparticles has been shown to enhance the reactivity of magnetic nanoparticles [21] . The silica shell can be readily customized through the formation of covalent bonds with a variety of surface functional groups [22] .…”

Section: Magnetic Oxide Core Shellmentioning

confidence: 99%

Engineered magnetic core shell nanoprobes: Synthesis and applications to cancer imaging and therapeutics

Mandal

Chaudhuri

2016

WJBC

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Magnetic core shell nanoparticles are composed of a highly magnetic core material surrounded by a thin shell of desired drug, polymer or metal oxide. These magnetic core shell nanoparticles have a wide range of applications in biomedical research, more specifically in tissue imaging, drug delivery and therapeutics. The present review discusses the up-to-date knowledge on the various procedures for synthesis of magnetic core shell nanoparticles along with their applications in cancer imaging, drug delivery and hyperthermia or cancer therapeutics. Literature in this area shows that magnetic core shell nanoparticle-based imaging, drug targeting and therapy through hyperthermia can potentially be a powerful tool for the advanced diagnosis and treatment of various cancers.

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“…30 In brief, the suspension of the citric acid-stabilized SPIONs was first diluted with ethanol (1:1 vol), and the pH was set to 11.0 using ammonia. Afterward, TEOS was added, and the mixture was magnetically stirred for 3 hours.…”

Section: Synthesis Of Surface Modified Spionsmentioning

confidence: 99%

“…XRD of the plain SPIONs showed a single spinel phase ( Figure 2E), whereas the chemical analyses showed that there was less than 3% of iron present in the oxidation state 2+, confirming that the NPs were composed of maghemite. 30 The changes in the surface charge of the SPIONs were followed by the zeta (ζ) potential measurements of their aqueous suspensions (pH 7.4) and in 10 mM HEPES buffer (pH 7.0). The ζ-potential values of the plain SPIONs, silica-coated SPIONs, SPIONs functionalized with amino or carboxyl groups are presented in Figure 2F.…”

Section: Characteristics Of Spions Liposomes and Lipid Assaymentioning

confidence: 99%

Effect of superparamagnetic iron oxide nanoparticles on fluidity and phase transition of phosphatidylcholine liposomal membranes

Santhosh

Drašler

Drobne

et al. 2015

IJN

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Superparamagnetic iron oxide nanoparticles (SPIONs) with multifunctional properties have shown great promise in theranostics. The aim of our work was to compare the effects of SPIONs on the fluidity and phase transition of the liposomal membranes prepared with zwitterionic phosphatidylcholine lipids. In order to study if the surface modification of SPIONs has any influence on these membrane properties, we have used four types of differently functionalized SPIONs, such as: plain SPIONs (primary size was shown to bê11 nm), silica-coated SPIONs, SPIONs coated with silica and functionalized with positively charged amino groups or negatively charged carboxyl groups (the primary size of all the surface-modified SPIONs was ~20 nm). Small unilamellar vesicles prepared with 1-palmitoyl-2-oleoyl- sn -glycero-3-phosphocholine lipids and multilamellar vesicles prepared with 1,2-dipalmitoyl- sn -glycero-3-phosphocholine lipids were encapsulated or incubated with the plain and surface-modified SPIONs to determine the fluidity and phase transition temperature of the bilayer lipids, respectively. Fluorescent anisotropy and differential scanning calorimetric measurements of the liposomes that were either encapsulated or incubated with the suspension of SPIONs did not show a significant difference in the lipid ordering and fluidity; though the encapsulated SPIONs showed a slightly increased effect on the fluidity of the model membranes in comparison with the incubated SPIONs. This indicates the low potential of the SPIONs to interact with the nontargeted cell membranes, which is a desirable factor for in vivo applications.

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Producing ultra-thin silica coatings on iron-oxide nanoparticles to improve their surface reactivity

Cited by 115 publications

References 15 publications

Sulphur-Containing Compounds as a Response in Sea Urchins Exposed to Alkylated Silicon Nanocrystals and SiO<sub>2</sub>-Coated Iron Oxide Nanoparticles

Sulphur-Containing Compounds as a Response in Sea Urchins Exposed to Alkylated Silicon Nanocrystals and SiO<sub>2</sub>-Coated Iron Oxide Nanoparticles

Engineered magnetic core shell nanoprobes: Synthesis and applications to cancer imaging and therapeutics

Effect of superparamagnetic iron oxide nanoparticles on fluidity and phase transition of phosphatidylcholine liposomal membranes

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