Citrus fruits are among the most produced and traded agricultural products worldwide, with significant economic and social importance. Despite their importance in the European Union, Middle East, and Africa, the existing literature is limited. Several studies have reviewed different aspects of general agri-food supply chains, but a product-based literature review on citrus supply chains has not been conducted. This paper provides a comprehensive review of the citrus supply chain in these regions, identifying the key research topics, methodologies, and supply chain echelons addressed in the literature. The study employed a systematic review, real-world case studies, and supply chain stakeholders’ interviews. This multi-faceted approach allows researchers to highlight research gaps, map a complete citrus supply chain, and provide a detailed material flow and sustainability-oriented overview of potential inputs and outputs at different stages. By incorporating real-world case studies and stakeholder interviews, this paper offers a nuanced and practical perspective on the operational and sustainability challenges unique to the citrus supply chain. This study serves as a guide for future research and enables practitioners to pinpoint areas and strategies for operational improvement across the supply chain.