2018
DOI: 10.3389/fmicb.2018.01918
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Production and Antimicrobial Activity of Nisin Under Enological Conditions

Abstract: Lactic acid bacteria (LAB) are responsible for the malolactic fermentation of wines, and, therefore, controlling the growth of these bacteria is a key factor for elaborating premium wines. Sulfur dioxide has been traditionally used as an efficient antimicrobial and antioxidant agent, however, nowadays consumers’ demand tends toward a reduction of sulfur dioxide levels in wine and other fermented foods. A previous study of our research group had demonstrated the effectiveness of the bacteriocin nisin to inhibit… Show more

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Cited by 15 publications
(6 citation statements)
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References 42 publications
(49 reference statements)
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“…Furthermore, the chemical-physical and compositional characteristics of the substrate are notoriously capable of modifying the stability and activity of the bacteriocin over time. The bacteriocin can interact with other macromolecules present in the substrate, losing its antimicrobial activity (Fernández-Pérez et al, 2018; Silva et al, 2018). Furthermore, nisin is susceptible to depletion due to its physical diffusion within the food system or its degradation by proteases (Sarkar et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the chemical-physical and compositional characteristics of the substrate are notoriously capable of modifying the stability and activity of the bacteriocin over time. The bacteriocin can interact with other macromolecules present in the substrate, losing its antimicrobial activity (Fernández-Pérez et al, 2018; Silva et al, 2018). Furthermore, nisin is susceptible to depletion due to its physical diffusion within the food system or its degradation by proteases (Sarkar et al, 2017).…”
Section: Discussionmentioning
confidence: 99%
“…PBDM peptides showed high antibacterial activity against gram positive bacteria as seen in nisin peptides but in case of VRE and E. faecalis the activity of PBDM peptides needed higher concentrations for prominent antibacterial efficacy. However, PBDM not only showed activity against gram positive bacteria but also was effective against gram negative bacteria which were not seen in case of nisin peptides without any modification ( Jozala et al, 2015 ; Shin et al, 2016 ; Vukomanović et al, 2017 ; Fernández-Pérez et al, 2018 ). So, further in vitro studies using human cell lines to study toxicity and in vivo studies were performed to check the antibacterial activity and biocompatibility against infected balb/c mice.…”
Section: Resultsmentioning
confidence: 89%
“…However, the significance of Lactococcus spp. for wine quality is not yet well established [5,44,59,60], seeming to possess relatively little resistance to ethanol [61,62].…”
Section: Origin and Dissemination Of The Wmc Throughout The Yearmentioning
confidence: 99%