2023
DOI: 10.1002/btpr.3390
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Production and characterization of a chimeric protein targeting synuclein epitopes for immunotherapy against synucleinopathies

Christian Carreño‐Campos,
Dania O. Govea‐Alonso,
Maria Luisa Villarreal
et al.

Abstract: The aggregation and spread of alpha‐synuclein (αSyn) is associated with several pathogenic pathways that lead to neurodegeneration and, ultimately, to synucleinopathies development. Hence, the establishment of a safe and effective disease‐modifying therapy that limits or prevents the spread of toxic αSyn aggregation could lead to positive clinical outcomes. A rational vaccine design can be focused on the selection of specific epitopes able to induce the immune response desired, for example, antibodies able to … Show more

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