“…Current research demonstrates that MB analogs also exhibit some degrees of contact toxicity. Among 15 chemicals tested, 10 are natural occurring compounds (MB 18 – 24 , EB 25 , M2MB 26 , M2MOB 27 , nPrB 28 , nBB 29 , nPeB 30 , iBB 31 , nHB 21 – 24 , 26 , BB 21 – 24 , 32 ) (Fig. 1 ), in which MB, EB, nPrB, M2MOB, iBB, and BB have been approved by the US Food and Drug Administration (21 CFR 172.515) 33 and the European Union (EU Regulation 1334/2008 & 178/2002) 34 for use as flavoring substances and adjuvants.…”