Production and characterization of bioactive metabolites from piezotolerant deep sea fungus<i>Nigrospora</i>sp. in submerged fermentation

Arumugam, Ganesh; Srinivasan, S.; Joshi, Gopal; Dharani, G.; Kirubagaran, Ramalingam

doi:10.1111/jam.12693

Cited by 41 publications

(32 citation statements)

References 56 publications

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“…When sucrose was used, the pigment concentration became maximum. This confirms the research; explaining, how the increment in carbon source enhances pigment production (Arumugam et al 2015) (Figure 5).…”

Section: Optimisation Of Pigment Productionsupporting

confidence: 89%

Extraction and optimisation of red pigment production as secondary metabolites from Talaromyces verruculosus and its potential use in textile industries

et al. 2017

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Textile dyes and effluents are considered as one of the worst polluters of our priceless water sources and soils. New sources of natural pigments are getting particular research interests due to the toxicity produced by synthetic colouring agents. Plant sources are being explored extensively for natural pigments but inadequate yield of those sources hampered the progression. Apart from the enormous antibacterial applications, fungi may provide a readily available alternative source of natural pigments. Here, we isolated a fungal strain from spoiled mango which is capable of producing pigments suitable for textile dyeing. The spoiled mangoes were selected as a source of different fungi. Among them one particular fungal isolate was selected for its visible production of secondary metabolites. Molecular identification using internal transcribed spacer sequencing revealed the fungi as Talaromyces verruculosus strain. The growth and pigment production of the fungi was optimised to obtain highest yield. Extracted pigment was applied to cotton fabric following a standard dyeing procedure for natural pigment. Adequate colour yield and negative cytotoxicity result suggested that the fungi source of pigment could be a potential replacement for hazardous synthetic dyes.

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Section: Optimisation Of Pigment Productionsupporting

confidence: 89%

Extraction and optimisation of red pigment production as secondary metabolites from Talaromyces verruculosus and its potential use in textile industries

et al. 2017

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“…Talaromyces amestolkiae produces red colorants that are of interest for the industry as they are stable and nontoxic and can be used as food colorants . Recent studies have highlighted the potential of using polyketide colorants from filamentous fungi as a functional food colorant as they showed relatively low cytotoxicity and antimicrobial activity . These studies are required by regulatory agencies for establishing T. amestolkiae as new and potentially safe source for the production of natural colorants.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 Recent studies have highlighted the potential of using polyketide colorants from filamentous fungi as a functional food colorant as they showed relatively low cytotoxicity and antimicrobial activity. 9,10 These studies are required by regulatory agencies for establishing T. amestolkiae as new and potentially safe source for the production of natural colorants. Altogether, consumer perception of the health value of natural colorants has been pushing the food colorants market to grow and leading the industry to remove artificial coloring from their products and focus on research and development of stable and functional ones.…”

Section: Introductionmentioning

confidence: 99%

Sequencing and phylogenetic analyses of talaromyces amestolkiae from amazon: A producer of natural colorants

Zaccarim

Oliveira

Passarini

et al. 2018

Biotechnology Progress

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The population interest in health products is increasing day-by-day. Thus, the demand for natural products to be added in food and pharmaceutical commodity is also rising. Among these additives, colorants, which provides color to products, can be produced by microorganism through bioprocess. Looking for new source of natural colorants, fungi have been employed to this purpose producing novel and safer natural colorants. So, the main goal of this study was to describe a Talaromyces species able to produce natural colorants and investigate nutritional parameters of colorants production using statistical tool. The taxonomy classified the microorganism as Talaromyces amestolkiae. The statistical design evaluated pH and glucose, meat extract and meat peptone concentration as independent variables, and red colorants production as main response. Under the best condition (g/L: glucose 30, meat extract 1, meat peptone 10, and initial pH of 7.0) an increase of 229% in the red colorant production was achieved as compared with the initial media used. The dried fermented broth containing red colorants showed low cytotoxicity against fibroblasts cells (IC > 187.5 g/L) and effective antimicrobial activity against S. aureus (MIC of 2.5 g/L). Thus, T. amestolkiae colorants can be attractive to food and pharmaceutical applications as it does not produce toxic compounds and can promote protection against microorganism contaminants. © 2018 American Institute of Chemical Engineers Biotechnol. Prog., 1-12, 2018.

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“…Furthermore, there are many reports about metabolites from Nigrospora spp. (Arumugam et al, 2014;Rathod et al, 2014;Ibrahim et al, 2018) that displayed good activity against pathogenic microorganisms. Some secondary metabolites (griseofulvin, spirobenzofuran and pyrazine) from Nigrospora spp.…”

Section: Gc-ms Analysismentioning

confidence: 99%

Antimicrobial and antioxidant activities of endophytic fungi extracts isolated from Carissa carandas

Supaphon¹,

Preedanon²

2019

Afr. J. Microbiol. Res.

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This is the first report of endophytic fungi derived from Carissa carandas producing bioactive compounds in Thailand. The aims of this research were to evaluate the antimicrobial and antioxidant activities of extracts from endophytic fungi, identify the potential fungal isolates by phylogenetic analysis and analyze the composition of the potential crude extract by gas chromatography-mass spectrometry (GC-MS). The endophytic fungus Nigrospora guilinensis TSU-EFHA009 produced the most active extracts. Broth ethyl acetate extract (BE) had the strongest activity against Cryptococcus neoformans at a minimum inhibitory concentration (MIC) of 4 µg/mL and a minimum fungicidal concentration of 8 µg/mL. Moreover, the antimicrobial activity was confirmed using scanning electron microscopy. The target cells were morphologically damaged. In addition, this active extract had the highest antioxidant activity with an inhibitory concentration (IC 50) value of 0.03 mg/mL. The total phenolic content of the target extract was detected by using the colorimetric method. This extract contained a total phenolic content of 41.20±0.40 mg GAE/g of the extract. The results indicated that the endophytic fungi from C. carandas are good sources of antimicrobial and antioxidant substances.

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Production and characterization of bioactive metabolites from piezotolerant deep sea fungusNigrosporasp. in submerged fermentation

Abstract: This is the first study exploring Nigrospora sp. from 800 m in marine environment. This deep sea fungus under optimized culture conditions effectively produced bioactive secondary metabolites such as griseofulvin, spirobenzofuran and pyrone derivatives at higher concentrations.

Cited by 41 publications

References 56 publications

Extraction and optimisation of red pigment production as secondary metabolites from Talaromyces verruculosus and its potential use in textile industries

Extraction and optimisation of red pigment production as secondary metabolites from Talaromyces verruculosus and its potential use in textile industries

Sequencing and phylogenetic analyses of talaromyces amestolkiae from amazon: A producer of natural colorants

Antimicrobial and antioxidant activities of endophytic fungi extracts isolated from Carissa carandas

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