Production and characterization of PCL (Polycaprolactone) coated TCP/nanoBG composite scaffolds by sponge foam method for orthopedic applications

Abstract

Bio-ceramics are a set of ceramic materials that possess an important feature called biocompatibility. Bioglass is one of the most applicable ceramic materials contributing to bioactivity improvement due to the presence of Si as an ossification material. Besides, PCL polymer supported by bioglass nanoparticles was used to improve the mechanical properties. In this study, we combined Tricalciumphosphate (TCP) with nano-bioglass (NBG) with four different amounts (10%, 20%, 30%, and 0%) to produce composite scaffolds (lost sponge foam method); then, we coated these composites by Polycaprolactone (PCL) biopolymer, and eventually, evaluated its bioactivity, biodegradability, and mechanical properties. Scanning electron microscopy (SEM) and EDS methods were employed to investigate the morphology and bioactivity of scaffolds. The results of the ion concentration measurement test and SEM and EDS analysis showed the formation of Apatite on the scaffold's surface. The results from SEM indicate that the most bioactivity was observed for composite scaffold containing 20%wt of nano-bioglass presenting it as the preferable sample, in terms of mechanical properties and bioactivity.

Nanodiamond-containing composites for tissue scaffolds and surgical implants: A review

“…Tissue scaffolds and surgical implants: Due to the restoring potential for damaged tissue, regenerative medicine, and tissue engineering are of great interest [174][175][176][177]. Like protein-coated materials, ND monolayers have been indicated to act as a suitable platform for the growth of neuronal cells [178].…”

An overview of the development of composites containing Mg and Zn for drug delivery

“…In recent decades, noticeable advancements have been observed in the design of chemotherapeutics. However, most chemotherapeutics have some limiting drawbacks such as high cytotoxicity, nonspecific and uncontrolled delivery, high drug dosing, lower solubility, poor absorption, and high side effects [61,62]. Therefore, it is needed to develop ideal drug delivery systems with some particular properties such as biodegradability, biocompatibility, high drug loading capacity, and capability of drug release in a controlled way.…”

Recent progress in materials used towards corrosion protection of Mg and its alloys

“…Recently, composite polymer coatings and their performance in the corrosion protection of Mg have attracted the attention of many researchers. The good corrosion resistance of super-dispersed polytetrafluoroethylene (SPTFE) [16][17][18], a composite of diethylenetriamine, polyetherimide, and hydroxyapatite [19], and composites graphene oxide (GO)-containing 4-ethylene dioxythiophene (PEDOT) has been reported for the protection of Mg and its alloys. Coatings based on diamond-like carbon (DLC) are also among recently-developed coatings for the protection of Mg alloys owing to their chemical inertness, low friction, and high hardness [20].…”