Production and evaluation of monovalent anti-snake immunoglobulins from chicken egg yolk using Ghanaian puff adder (Bitis arietans) Venom: Isolation, purification, and neutralization efficacy

Gyawu, Vincent Baffour; Firempong, Caleb Kesse; Hamidu, Jacob Alhassan; Tetteh, Antonia Yarney; Ti-Baliana Martha, Naab Justine; Yingshu, Feng; Yi, Zou

doi:10.1016/j.toxicon.2023.107180

Cited by 5 publications

(1 citation statement)

References 46 publications

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“…Numerous clinical trials have shown that oral IgY is effective in preventing and treating neonatal diarrhea and vomiting caused by rotavirus. Specialized IgY could prevent rotavirus from adsorbing to the body cells and enhance phagocytosis of macrophages by modifying the configuration of the virus surface [94] . Similarly, as a relatively readily available and inexpensive immunoglobulin, IgY has shown excellent therapeutic efficacy in eliminating the side effects of snake venom.…”

Section: Antibacterial and Immune Enhancing Mechanisms Of Igymentioning

confidence: 99%

Eggstraordinary health: exploring avian egg proteins and peptides in boosting immunity and health maintenance

Li,

Xia,

Zeng

et al. 2023

Food Science of Animal Products

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Amidst the outbreak of the Corona Virus Disease 2019 , there has been a pivotal shift in nutritional focus towards adopting healthier lifestyles to enhance immune function. The successive resurgence of COVID-19 serves as a stark reminder that prioritizing the enhancement of our own immune systems is of paramount importance. Eggs are nutritious, productive, cost-effective, and affordable for consumption. Likewise, eggs are exclusive among the numerous ways consumers can obtain high-quality animal protein.Egg proteins and their peptide derivatives are abundant and biologically active and have significant therapeutic effects on chronic diseases induced by a variety of factors, including metabolic syndrome, making eggs an important raw material for the study of proteins and peptide-active substances. This paper reviewed methods for the isolation and purification of avian egg proteins and their derived peptides; the effects of the proteins and peptides in enhancing the body's immunity, lowering blood pressure and expression levels of inflammatory factors; as well as the potential of the proteins and peptides in reducing the risk of chronic diseases such as osteoporosis and cardiovascular disease. This review was written with the expectation that it would provide a comprehensive understanding of the potential value of poultry egg proteins for maintaining health.

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Section: Antibacterial and Immune Enhancing Mechanisms Of Igymentioning

confidence: 99%

Eggstraordinary health: exploring avian egg proteins and peptides in boosting immunity and health maintenance

Li,

Xia,

Zeng

et al. 2023

Food Science of Animal Products

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Kaempferol mitigates reproductive dysfunctions induced by Naja nigricollis venom through antioxidant system and anti-inflammatory response in male rats

Adeyi,

Ajisebiola,

Sanni

et al. 2024

Sci Rep

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Naja nigricollis Venom (NnV) contains complex toxins that affects various vital systems functions after envenoming. The venom toxins have been reported to induce male reproductive disorders in envenomed rats. This present study explored the ameliorative potential of kaempferol on NnV-induced male reproductive toxicity. Fifty male wistar rats were sorted randomly into five groups (n = 10) for this study. Group 1 were noted as the control, while rats in groups 2 to 5 were injected with LD50 of NnV (1.0 mg/kg bw; i.p.). Group 2 was left untreated post envenomation while group 3 was treated with 0.2 ml of polyvalent antivenom. Groups 4 and 5 were treated with 4 and 8 mg/kg of kaempferol, respectively. NnV caused substantial reduction in concentrations of follicle stimulating hormone, testosterone and luteinizing hormone, while sperm motility, volume and counts significantly (p < 0.05) decreased in envenomed untreated rats. The venom enhanced malondialdehyde levels and substantially decreased glutathione levels, superoxide dismutase and glutathione peroxidase activities in the testes and epididymis of envenomed untreated rats. Additionally, epididymal and testicular myeloperoxidase activity and nitric oxide levels were elevated which substantiated severe morphological defects noticed in the reproductive organs. However, treatment of envenomed rats with kaempferol normalized the reproductive hormones with significant improvement on sperm functional parameters. Elevated inflammatory and oxidative stress biomarkers in testis and epididymis were suppressed post kaempferol treatment. Severe histopathological lesions in the epididymal and testicular tissues were ameliorated in the envenomed treated groups. Results highlights the significance of kaempferol in mitigating reproductive toxicity induced after snakebite envenoming.

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Development of chicken egg yolk antibodies (IgY) against venom of cobra ( Naja naja) and krait (Bungarus caeruleus) and a study on its neutralization potential

Gopal,

Antonysamy,

Visaga Ambi

et al. 2024

Toxin Reviews

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Production and evaluation of monovalent anti-snake immunoglobulins from chicken egg yolk using Ghanaian puff adder (Bitis arietans) Venom: Isolation, purification, and neutralization efficacy

Cited by 5 publications

References 46 publications

Eggstraordinary health: exploring avian egg proteins and peptides in boosting immunity and health maintenance

Eggstraordinary health: exploring avian egg proteins and peptides in boosting immunity and health maintenance

Kaempferol mitigates reproductive dysfunctions induced by Naja nigricollis venom through antioxidant system and anti-inflammatory response in male rats

Development of chicken egg yolk antibodies (IgY) against venom of cobra ( Naja naja) and krait (Bungarus caeruleus) and a study on its neutralization potential

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