Production and optimization of a vasostatin-30 and vasoinhibin fusion protein that inhibits tumor angiogenesis and dissemination of breast cancer cells in a zebrafish model

Rodriguez, Gabriela Vazquez; Avalos, Edgar R. Juvera; González, Carmen; Rosa, Ana; León‐Rodríguez, Antonio De

doi:10.1016/j.procbio.2022.05.002

Process Biochemistry

2022

DOI: 10.1016/j.procbio.2022.05.002

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Production and optimization of a vasostatin-30 and vasoinhibin fusion protein that inhibits tumor angiogenesis and dissemination of breast cancer cells in a zebrafish model

Gabriela Vazquez Rodriguez

Edgar R. Juvera Avalos

Carmen González

et al.

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Natural products targeting tumour angiogenesis

Lu,

Friedrich,

Efferth

2023

British J Pharmacology

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Tumor angiogenesis is the formation of new blood vessels to support the growth of a tumor. This process is critical for tumor progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals, or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumor growth and progression. In this review, we comprehensively report on the current status of natural products against tumor angiogenesis from four perspectives until March 2023: 1) the role of pro‐angiogenic factors and antiangiogenic factors in tumor angiogenesis; 2) the development of anti‐tumor angiogenesis therapy (monoclonal antibodies, VEGFR‐targeted small molecules, and fusion proteins); 3) the summary of anti‐angiogenic natural agents, including polyphenols, polysaccharides, alkaloids, terpenoids, saponins and their mechanisms of action; 4) the future perspectives of anti‐angiogenic natural products (bioavailability improvement, testing of dosage and side effects, combination use, and discovery of unique natural‐based compounds). Our review aims to better understand the potential of natural products for drug development in inhibiting tumor angiogenesis and further aid the effective transition of these outcomes into clinical trials.

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Natural products targeting tumour angiogenesis

Lu,

Friedrich,

Efferth

2023

British J Pharmacology

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show abstract

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Production and optimization of a vasostatin-30 and vasoinhibin fusion protein that inhibits tumor angiogenesis and dissemination of breast cancer cells in a zebrafish model

Cited by 1 publication

References 58 publications

Natural products targeting tumour angiogenesis

Natural products targeting tumour angiogenesis

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