Production and purification of glucosamine and angiotensin-I converting enzyme (ACE) inhibitory peptides from mushroom hydrolysates

A mushroom diet reduced the risk of pregnancy-induced hypertension and macrosomia: a randomized clinical trial

“…Mushrooms contain various nutrients, and are particularly rich in ergothioneine, a strong antioxidant that has the function of protecting endothelial cells (12). Moreover, mushrooms contain a natural antihypertensive agent, angiotensin-I converting enzyme inhibitory peptide (14). In short, the rational of the study design was in accordance with the well-documented benefits of mushrooms.…”

Isolation and identification of the angiotensin-I converting enzyme (ACE) inhibitory peptides derived from cottonseed protein: optimization of hydrolysis conditions

“…Since then, many other ACE inhibitory peptides have been produced from enzymatic hydrolysates of different food proteins, such as casein, whey protein, mushroom, walnuts meal, wheat protein, fish protein, soybean protein, rapeseed protein, and marine organisms protein etc. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] Cottonseed protein is the second-best potential source of plant proteins. [22] Six proteases including flavourzyme, neutrase, alcalase, papain, pepsin, and trypsin have been used to digest cottonseed protein for the production of ACE inhibitory peptides.…”

Identification and Molecular Docking Study of a Novel Angiotensin-I Converting Enzyme Inhibitory Peptide Derived from Enzymatic Hydrolysates of Cyclina sinensis

“…This enzyme increases the production of angiotensin II by the renin-angiotensin system (RAS) [ 5 ], decreases the level of bradykinin produced by the kallikrein-kinin system (KKS) [ 6 ], and plays a critical physiological role in the regulation of peripheral blood pressure and electrolyte homeostasis. Therefore, a key to the treatment and prevention of hypertension is the effective inhibition of ACE activity [ 7 ].…”