Production and radiochemical separation of a potential immuno-PET imaging agent 89Zr from proton irradiated natY target

Das, Sujata Saha; Chattopadhyay, Sankha; Barua, Luna; Alam, Md. Nayer; Madhusmita,; Kumar, Umesh

doi:10.1007/s10967-017-5316-9

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…The zirconium-89 radionuclide is widely used radiotracer in different fields of interest. Medical applications include immuno imaging, cell imaging, tumor cell therapy, antibody imaging and pharmacokinetics [1][2][3][4][5][6]. In geochemical and environmental studies zirconium-89 is used as a surrogate for tetravalent actinides e.g.…”

Section: Introductionmentioning

confidence: 99%

Production of no-carrier-added 89Zr at an 18 MeV cyclotron, its purification and use in investigations in solvent extraction

Mansel

Franke

2021

J Radioanal Nucl Chem

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The chemical separation of zirconium from lanthanides by liquid–liquid extraction is challenging but critical for medical and technological applications. Using the example of 89Zr, we optimize the liquid–liquid-extraction process by means of the radiotracer technique. We produced 89Zr by proton irradiation of a metallic yttrium target at a cyclotron. The purification of the radionuclide was performed by a UTEVA resin. 89Zr was separated in no-carrier-added form in a sulfuric acid solution. 89Zr was successfully used in solvent extraction tests with calixarenes for the separation of zirconium from lanthanides. This reaction is suitable for the efficient extraction and purification of lanthanides.

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Section: Introductionmentioning

confidence: 99%

Production of no-carrier-added 89Zr at an 18 MeV cyclotron, its purification and use in investigations in solvent extraction

Mansel

Franke

2021

J Radioanal Nucl Chem

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“…For the isolation of zirconium-89 from the irradiated target, cation- [37,38,39] and anion-exchange [23,40,41] chromatography methods, and extraction [38,41,42] were proposed. A typical procedure for processing the target is as follows: The irradiated target is dissolved in concentrated hydrochloric acid (9–12 M HCl).…”

Section: Introductionmentioning

confidence: 99%

Preparation of Zirconium-89 Solutions for Radiopharmaceutical Purposes: Interrelation Between Formulation, Radiochemical Purity, Stability and Biodistribution

et al. 2019

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Zirconium-89 is a promising radionuclide for nuclear medicine. The aim of the present work was to find a suitable method for obtaining zirconium-89 solutions for radiopharmaceutical purposes. For this purpose, the ion exchange behavior of zirconium-89 solutions was studied. Radio-TLC (thin layer chromatography) and biodistribution studies were carried out to understand speciation of zirconium-89 complexes and their role in the development of new radiopharmaceuticals. Three methods of zirconium-89 isolation were studied using ZR (hydroxamate) and Chelex-100 resins. It was found that ZR-resin alone is not enough to obtain stable zirconium-89 formulations. An easy and effective method of reconstitution of [89Zr]Zr-oxalate to [89Zr]Zr-citrate using Chelex-100 resin was developed. Developed procedures allow obtaining [89Zr]Zr-oxalate (in 0.1 M sodium oxalate solution) and [89Zr]Zr-citrate (in 0.1–1.0 M sodium citrate solution). These solutions are perfectly suitable and convenient for radiopharmaceutical purposes. Our results prove [89Zr]Zr-citrate to be advantageous over [89Zr]Zr-oxalate. During evaluation of speciation of zirconium-89 complexes, a new TLC method was developed, since it was proved that there is no comprehensive method for analysis or zirconium-89 preparations. The new method provides valuable insights about the content of “active” ionic form of zirconium-89. The interrelation of the chromatographic behavior of zirconium-89 preparations and their biodistribution was studied.

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Purification of 99Mo and 99mTc from radioactive traces of Nb, Zr, and Y impurities: method applicable in the purification of the spent 100/99Mo–99mTc generator

Chattopadhyay

Das

Madhusmita

et al. 2019

J Radioanal Nucl Chem

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Production and radiochemical separation of a potential immuno-PET imaging agent 89Zr from proton irradiated natY target

Cited by 6 publications

References 18 publications

Production of no-carrier-added 89Zr at an 18 MeV cyclotron, its purification and use in investigations in solvent extraction

Production of no-carrier-added 89Zr at an 18 MeV cyclotron, its purification and use in investigations in solvent extraction

Preparation of Zirconium-89 Solutions for Radiopharmaceutical Purposes: Interrelation Between Formulation, Radiochemical Purity, Stability and Biodistribution

Purification of 99Mo and 99mTc from radioactive traces of Nb, Zr, and Y impurities: method applicable in the purification of the spent 100/99Mo–99mTc generator

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