Production and Recovery of Lactic Acid for Polylactide—An Overview

Vaidya, Atul N.; Pandey, R.A.; Mudliar, Sandeep N.; Kumar, M Suresh; Chakrabarti, Tapan; Devotta, S.

doi:10.1080/10643380590966181

Cited by 121 publications

(82 citation statements)

References 31 publications

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“…Several reviews have been published about novel substrates and developments of biotechnology processes for lactic acid production by fermentation (Vaidya et al 2005;Datta and Henry 2006;Abdel-Rahman et al 2011;Abdel-Rahman et al 2013).…”

Section: Bioresourcescommentioning

confidence: 99%

Lactic Acid Production to Purification: A Review

Komesu

Oliveira

Martins

et al. 2017

BioRes

207

114

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Lactic acid is a naturally occurring organic acid that can be used in a wide variety of industries, such as the cosmetic, pharmaceutical, chemical, food, and, most recently, the medical industries. It can be made by the fermentation of sugars obtained from renewable resources, which means that it is an eco-friendly product that has attracted a lot of attention in recent years. In 2010, the U.S. Department of Energy issued a report that listed lactic acid as a potential building block for the future. Bearing the importance of lactic acid in mind, this review summarizes information about lactic acid properties and applications, as well as its production and purification processes.

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Section: Bioresourcescommentioning

confidence: 99%

Lactic Acid Production to Purification: A Review

Komesu

Oliveira

Martins

et al. 2017

BioRes

207

114

View full text Add to dashboard Cite

show abstract

“…Lactic acid bacteria have complex nutrient requirements due to their limited ability to biosynthesize B-vitamins and amino acids. These comprise many of the known vitamins, amino acids and even small peptides [23,24]. By the way, supplementation of nutrients introduces additional cost to production of lactic acid beside their positive effects.…”

Section: Introductionmentioning

confidence: 99%

The effects of nutrient supplements on the production of lactic acid from cheese whey

Eldeleklioğlu¹,

Bayraktar

Mehmetoǧlu³

2013

Turk J Bioch

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“…An example is polylactic acid, a renewable, biodegradable, and environmentally friendly polymer produced from D-and L-lactate (19). In this context, biological processes have the advantage of being able to produce chirally pure lactate from inexpensive media containing only the carbon source and mineral salts (43). While lactic acid bacteria traditionally have been used in the production of D-lactate from carbohydraterich feedstocks, several laboratories recently have reported alternative biocatalysts (13,30), many of which are engineered Escherichia coli strains that produce D-or L-lactate (4,8,50,51,52).…”

mentioning

confidence: 99%

Escherichia coli Strains Engineered for Homofermentative Production of d -Lactic Acid from Glycerol

Mazumdar

Clomburg

González

2010

Appl Environ Microbiol

145

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Given its availability and low price, glycerol has become an ideal feedstock for the production of fuels and chemicals. We recently reported the pathways mediating the metabolism of glycerol in Escherichia coli under anaerobic and microaerobic conditions. In this work, we engineer E. coli for the efficient conversion of glycerol to D-lactic acid (D-lactate), a negligible product of glycerol metabolism in wild-type strains. A homofermentative route for D-lactate production was engineered by overexpressing pathways involved in the conversion of glycerol to this product and blocking those leading to the synthesis of competing by-products. The former included the overexpression of the enzymes involved in the conversion of glycerol to glycolytic intermediates (GlpK-GlpD and GldA-DHAK pathways) and the synthesis of D-lactate from pyruvate (D-lactate dehydrogenase). On the other hand, the synthesis of succinate, acetate, and ethanol was minimized through two strategies: (i) inactivation of pyruvate-formate lyase (⌬pflB) and fumarate reductase (⌬frdA) (strain LA01) and (ii) inactivation of fumarate reductase (⌬frdA), phosphate acetyltransferase (⌬pta), and alcohol/acetaldehyde dehydrogenase (⌬adhE) (strain LA02). A mutation that blocked the aerobic D-lactate dehydrogenase (⌬dld) also was introduced in both LA01 and LA02 to prevent the utilization of D-lactate. The most efficient strain (LA02⌬dld, with GlpK-GlpD overexpressed) produced 32 g/liter of D-lactate from 40 g/liter of glycerol at a yield of 85% of the theoretical maximum and with a chiral purity higher than 99.9%. This strain exhibited maximum volumetric and specific productivities for D-lactate production of 1.5 g/liter/h and 1.25 g/g cell mass/h, respectively. The engineered homolactic route generates 1 to 2 mol of ATP per mol of D-lactate and is redox balanced, thus representing a viable metabolic pathway.

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Production and Recovery of Lactic Acid for Polylactide—An Overview

Cited by 121 publications

References 31 publications

Lactic Acid Production to Purification: A Review

Lactic Acid Production to Purification: A Review

The effects of nutrient supplements on the production of lactic acid from cheese whey

Escherichia coli Strains Engineered for Homofermentative Production of d -Lactic Acid from Glycerol

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