Production and secretion of 5 -dihydrotestosterone by the dog testis

Folman, Y.; Gc, Haltmeyer; Eik-Nes, KB

doi:10.1152/ajplegacy.1972.222.3.653

Cited by 32 publications

(16 citation statements)

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“…The true specific radioactivity of secreted testosterone was higher than that of secreted DHT (Table 3), a finding which repeats that of work already published from our laboratory (Folman et al, 1972). Nonradioactive testosterone could also be determined in 2-ml samples of spermatic lymph, but the concentrations of non-radioactive DHT in such volumes of spermatic lymph were too low to be determined with adequate precision (Haltmeyer & Eik-Nes, 1972a).…”

Section: Resultssupporting

confidence: 82%

“…Some of the DHT produced from testosterone in the testis of the dog (Folman et al, 1972) leaves this gland through the spermatic lymph (Table 1). Since the flow of lymph from the dog testis (Table 1) is much lower than that of spermatic venous blood (Eik-Nes, 1962), the quantitative significance of lymphatic transport of testosterone or DHT from the testis of the dog is minute.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, both progesterone and its 20a-reduced metabolite can be measured in the ovarian lymph of the ewe obtained during pregnancy or the luteal phase of the oestrous cycle (Lindner, Sass & Morris, 1964). It was recently shown in our laboratory that testes of anaesthetized dogs produce and secrete 5a-dihydrotestosterone (Folman, Haltmeyer & Eik-Nes, 1972). Since 5a-dihydrotestosterone (DHT) is a potent androgen, it was deemed important to determine the concentration of DHT in the testicular lymph.…”

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confidence: 99%

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Transport of 5 -Dihydrotestosterone by Testicular Lymph in the Dog

Haltmeyer¹,

Eik‐Nes²

1974

Reproduction

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When [3H]testosterone was infused through the spermatic artery of anaesthetized dogs, [3H] testosterone and [3H]5\m=infty\-dihydrotestosterone could be found both in the lymph and in the spermatic venous blood from the infused gonad. The concentration of radioactive testosterone and dihydrotestosterone per ml of testicular lymph was comparable to that per ml of spermatic venous blood. Because of the marked difference in flow rate, most of the androgens were, however, delivered from the testis through the spermatic vein.

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Section: Resultssupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Transport of 5 -Dihydrotestosterone by Testicular Lymph in the Dog

Haltmeyer¹,

Eik‐Nes²

1974

Reproduction

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“…In acute experiments (75 min duration) in the dog [6,13], administration of human chorionic gonado tropin (HCG) via the spermatic artery gives a sizable increase in T secretion but only a minute increase in the secretion of DHT. The concentration of DHT in testicular tissue of rats exposed to HCG for 18 h is lower than that of control animals (table X).…”

Section: Discussionmentioning

confidence: 99%

“…The animal preparation used in this work has been described elsewhere [7] and the data are from work by Folman el al. [13]. One testis was infused with the animals own arterial blood and 3H-T at a constant rate via the spermatic artery, while the other testis was infused with blood, 3H-T and HCG.…”

Section: T and Dht In The Isolated Dog Testismentioning

confidence: 99%

Production and Secretion of 5α-Dihydrotestosterone by Male Reproductive Organs

Eik‐Nes¹

1971

Gynecol Obstet Invest

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The androgen 5Α-dihydrotestosterone (DHT) has been isolated and identified in testicular tissue (rats, dogs) and in testicular venous blood of the canine testis. Conversion of ³H-testosterone (T) to ³H-DHT in vitro by testicular tissue from rats treated with follicle-stimulating hormone in vivo tended to increase. No such effect of human chorionic gonadotropin treatment could be observed. The Leydig cells of testes from mature rats contribute little to the formation in vitro of ³H-DHT from ³H-T. Both these androgens can be found in spermatic lymph and in epididymal tissue of the dog. In an isolated prostate preparation where the gland is infused via the prostatic arteries with the animal’s arterial blood at a constant rate, DHT can be found in effluent blood. The dog prostate both produces and secretes DHT. The purpose of DHT production and secretion by male reproductive organs is discussed.

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