Production and secretion of calcitonin gene-related peptide from human lymphocytes

Wang, Hongcheng; Xing, Liyu; Li, Wenjing; Hou, Lingfei; Guo, Jun; Wang, Xian

doi:10.1016/s0165-5728(02)00221-7

Cited by 61 publications

(37 citation statements)

References 31 publications

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“…Previously it was demonstrated in other tissues that certain conditions, e.g., inflammation, can induce the secretion and release of different neuropeptides from immunocytes (lymphocytes, macrophages, eosinophils) [18, [38][39][40]. Human monocytes and lymphocytes express the SP gene at both the mRNA and the protein level [41,42], as well as CGRP [43]. The study of purified B and T cells confirmed that only activated lymphocytes were able to synthesize NPY [44] and TH [45].…”

Section: Discussionmentioning

confidence: 99%

Neuroimmune Link in the Mucosa of Chronic Gastritis with Helicobacter pylori Infection

et al. 2006

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It is suggested that different neuropeptides regulate gastric mucosal integrity and participate in the development of chronic gastritis. The aim of this study was to examine the roles and changes of immunoreactive (IR) nerves and immunocompetent cells in human gastritis. Immunohistochemical, immunocytochemical, and confocal laser microscopic methods were used. All investigated nerve fibers were found in different quantities in the mucosa of both control and gastritis samples. The number of SP, NPY, and VIP IR nerve fibers increased significantly (P < 0.05) in gastritis. No IR immunocompetent cells (lymphocytes, plasma cells, mast cells) were found in the control, however, some showed NPY (16.8%) and SP (9.4%) immunoreactivity in chronic gastritis. The distance between nerve fibers and immunocompetent cells was 200 nm to 1 microm. In conclusion, the increased number of SP, NPY, and VIP IR nerves and IR immunocytes suggests that they participate in development of neurogenic inflammation, repairing processes of chronic gastritis.

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Section: Discussionmentioning

confidence: 99%

Neuroimmune Link in the Mucosa of Chronic Gastritis with Helicobacter pylori Infection

et al. 2006

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“…Numerous neuropeptides are expressed and released from sensory as well as autonomic cutaneous nerves, including calcitonin gene related peptide (CGRP), substance P, neurokinin A, and vasoactive intestinal peptide (VIP) (13). In addition, cutaneous cells themselves such as keratinocytes, micro-vascular endothelial cells, merkel cells, fibroblasts or leukocytes are capable of releasing neuropeptides (18,19). The presence of neuropeptides in free nerve fibre endings and the proximity of these endings to a variety of cells in the skin seem to associate the cutaneous nervous system not merely for its role in sensation but in other biological actions as well, namely wound healing (20).…”

Section: Skin Innervationmentioning

confidence: 99%

The Role of Neuromediators and Innervation in Cutaneous Wound Healing

Ashrafi¹,

Baguneid²,

Bayat³

2016

Acta Derm Venerol

100

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The skin is densely innervated with an intricate network of cutaneous nerves, neuromediators and specific receptors which influence a variety of physiological and disease processes. There is emerging evidence that cutaneous innervation may play an important role in mediating wound healing. This review aims to comprehensively examine the evidence that signifies the role of innervation during the overlapping stages of cutaneous wound healing. Numerous neuropeptides that are secreted by the sensory and autonomic nerve fibres play an essential part during the distinct phases of wound healing. Delayed wound healing in diabetes and fetal cutaneous regeneration following wounding further highlights the pivotal role skin innervation and its associated neuromediators play in wound healing. Understanding the mechanisms via which cutaneous innervation modulates wound healing in both the adult and fetus will provide opportunities to develop therapeutic devices which could manipulate skin innervation to aid wound healing.

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“…Despite similarities in structure, a large variety of neuropeptides have been identified; some of them have been generated by posttranslational modifications of a precursor molecule. In addition, recently, cutaneous cells themselves such as keratinocytes, microvascular endothelial cells, Merkel cells, fibroblasts, or leukocytes were found to be capable of releasing neuropeptides under physiological circumstances (477,919).…”

Section: B Cutaneous Neuropeptides and Neuropeptide Receptor Biologymentioning

confidence: 99%

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman¹,

Goerge

Schneider

et al. 2006

Physiological Reviews

556

521

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This review focuses on the role of the peripheral nervous system in cutaneous biology and disease. During the last few years, a modern concept of an interactive network between cutaneous nerves, the neuroendocrine axis, and the immune system has been established. We learned that neurocutaneous interactions influence a variety of physiological and pathophysiological functions, including cell growth, immunity, inflammation, pruritus, and wound healing. This interaction is mediated by primary afferent as well as autonomic nerves, which release neuromediators and activate specific receptors on many target cells in the skin. A dense network of sensory nerves releases neuropeptides, thereby modulating inflammation, cell growth, and the immune responses in the skin. Neurotrophic factors, in addition to regulating nerve growth, participate in many properties of skin function. The skin expresses a variety of neurohormone receptors coupled to heterotrimeric G proteins that are tightly involved in skin homeostasis and inflammation. This neurohormone-receptor interaction is modulated by endopeptidases, which are able to terminate neuropeptide-induced inflammatory or immune responses. Neuronal proteinase-activated receptors or transient receptor potential ion channels are recently described receptors that may have been important in regulating neurogenic inflammation, pain, and pruritus. Together, a close multidirectional interaction between neuromediators, high-affinity receptors, and regulatory proteases is critically involved to maintain tissue integrity and regulate inflammatory responses in the skin. A deeper understanding of cutaneous neuroimmunoendocrinology may help to develop new strategies for the treatment of several skin diseases.

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Production and secretion of calcitonin gene-related peptide from human lymphocytes

Cited by 61 publications

References 31 publications

Neuroimmune Link in the Mucosa of Chronic Gastritis with Helicobacter pylori Infection

Neuroimmune Link in the Mucosa of Chronic Gastritis with Helicobacter pylori Infection

The Role of Neuromediators and Innervation in Cutaneous Wound Healing

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

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