Production and separation of 111In: an important radionuclide in life sciences: a mini review

Lahiri, Susanta; Maiti, Moumita; Ghosh, Kaustab

doi:10.1007/s10967-012-2344-3

Cited by 39 publications

(17 citation statements)

References 58 publications

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“…It is also used in LEDs and high-efficiency photovoltaic cells, markets that have seen rapid growth and are predicted to continue expanding (6,8). A relatively small use of indium, though one that could lead to significant exposure, is the use of a radioisotope 111 In for medical imaging and biodistribution studies (7,9).…”

Section: Usesmentioning

confidence: 99%

Exposure Potential and Health Impacts of Indium and Gallium, Metals Critical to Emerging Electronics and Energy Technologies

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2016

Curr Envir Health Rpt

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The rapid growth of new electronics and energy technologies requires the use of rare elements of the periodic table. For many of these elements, little is known about their environmental behavior or human health impacts. This is true for indium and gallium, two technology critical elements. Increased environmental concentrations of both indium and gallium create the potential for increased environmental exposure, though little is known about the extent of this exposure. Evidence is mounting that indium and gallium can have substantial toxicity, including in occupational settings where indium lung disease has been recognized as a potentially fatal disease caused by the inhalation of indium particles. This paper aims to review the basic chemistry, changing environmental concentrations, potential for human exposure, and known health effects of indium and gallium.

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Section: Usesmentioning

confidence: 99%

Exposure Potential and Health Impacts of Indium and Gallium, Metals Critical to Emerging Electronics and Energy Technologies

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2016

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“…Recently, production using various activation routes of heavier ions such as In and chemical separation methodologies has been reported [4][5][6]. Also,…”

Section: And 115mmentioning

confidence: 99%

Separation of Cyclotron Produced In-111 (III) from Cadmium (II) and Copper (II) Ions Using Ion Exchange Technique in Different Media

Ha¹,

M²

2016

Chem Sci J

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The commercial cation exchangers TSKgel BioAssist S, TSKgel CM-2SW and TSKgel CM-STAT have been used for the separation of 111 In (III) from Cd (II) and Cu (II) ions. The separation was carried out using low cost cation exchangers based on the differences in the sorption affinity of In, Cu and Cd towards the ion exchanger from 0.01 mol L -1 HCl. The effects of various parameters such as shaking time, HCl concentration and acetate buffer concentration were examined. A comparative study between cation exchangers showed the best one for radiochemical separation yielded more than 98% within 50 min by using column study.Conventional techniques were reported for separation of In-111 from Cd target using different types of cation exchangers [7], and synthetic polymeric resins [8]. A chromatographic method using inorganic ion exchanger (zirconium oxide) for radiochemical separation of non-carrier added In-115 from Cd-115 over a column of zirconium oxide was described [9]. Recently, numerous alternative techniques have been examined for the separation of indium from cadmium and copper using silica extracted agricultural wastes. Column separation technique is widely applied to separate 111 In from interfering ions based on the evaluation of distribution coefficient K d .Modern separation techniques for separation of Ga(II) using poly(acrylamide-acrylic acid disodium EDTA) were studied. The prepared inorganic ion exchangers used separation of radioactive elements such as cesium [10].In the present work we investigated the possibility of using cation exchangers for separation of radioindium from cadmium and copper, the distribution coefficients of the three elements on different types of cation exchangers were measured in 0.01 M HCl, acetate buffer at pH 4 and EDTA (10 -3 M) to find the best conditions for separation. Materials and Methods MaterialsIndium metal (99.9% purity,), anhydrous cadmium chloride (CdCl 2 ), cupric chloride dehydrate (CuCl 2 .2H 2 O), sodium hydroxide (NaOH), anhydrous sodium acetate (CH 3 COONa), Diethylene Tetramine Penta Acetic acid (DTPA), and Ethylene Diamine Tetra Acetic acid (EDTA) were reagent grade chemicals and supplied by Merck (Darmstadt, Germany). Chemical Sciences JournalChem ic a l S cience s J o u rnal

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“…One of the mostly used radionuclides 111 In (T 1/2 = 2.80 days) finds its applications in the labeling of cellular blood components, monoclonal antibodies, myocardial damage detections, localization of abscess in polycystic kidneys, radiolabeled immunoglobulin therapies, imaging for cancer, etc. Apart from this, 111 In is also used as a probe in c-c time differential perturbed angular correlations (TDPAC) studies [25,26].…”

Section: Applicationsmentioning

confidence: 99%

Comparison on the production of radionuclides in 1.4 GeV proton irradiated LBE targets of different thickness

Maiti

Ghosh

Mendonça

et al. 2014

J Radioanal Nucl Chem

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Production and separation of 111In: an important radionuclide in life sciences: a mini review

Cited by 39 publications

References 58 publications

Exposure Potential and Health Impacts of Indium and Gallium, Metals Critical to Emerging Electronics and Energy Technologies

Exposure Potential and Health Impacts of Indium and Gallium, Metals Critical to Emerging Electronics and Energy Technologies

Separation of Cyclotron Produced In-111 (III) from Cadmium (II) and Copper (II) Ions Using Ion Exchange Technique in Different Media

Comparison on the production of radionuclides in 1.4 GeV proton irradiated LBE targets of different thickness

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