1962
DOI: 10.1038/193579b0
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Production and Utilization of Free Acetate in Man

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Cited by 114 publications
(44 citation statements)
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“…In con-trast, blood acetate concentrations in man are normally <0.2 mM (5) except after ethanol consumption, in which case arterial plasma acetate levels are elevated by as much as 20-fold (6). It was during ethanol infusion and at -1.5 mM plasma acetate that Lundquist (7) estimated that the maximum utilization rate of acetate in man was 300 mmol/h. To our knowledge, however, plasma acetate production and utilization have not been measured directly in man.…”
Section: Introductionmentioning
confidence: 99%
“…In con-trast, blood acetate concentrations in man are normally <0.2 mM (5) except after ethanol consumption, in which case arterial plasma acetate levels are elevated by as much as 20-fold (6). It was during ethanol infusion and at -1.5 mM plasma acetate that Lundquist (7) estimated that the maximum utilization rate of acetate in man was 300 mmol/h. To our knowledge, however, plasma acetate production and utilization have not been measured directly in man.…”
Section: Introductionmentioning
confidence: 99%
“…Acetate is present in the circulating blood in appreciable concentrations only during ethanol metabolism, in which case the arterial concentration is fairly constant and within limits independent of the blood alcohol concentration (1). As ethanol is not metabolized in peripheral organs to any large extent, ingestion of small quantities of alcohol would appear to provide suitable conditions for the study of acetate utilization in the human body without interfering with acid-base metabolism (2).…”
Section: Introductionmentioning
confidence: 99%
“…In brief, a solution that increases the body's strong ion difference (the concentration of strong cations minus strong anions) will increase serum pH [15]. After injection and cellular uptake, the two-carbon acetate anion forms acetyl CoA and enters the citric acid cycle; the final by-products, carbon dioxide and water, are in a rapid equilibrium with bicarbonate through the catalyst activity of carbonic anhydrase [16,17]. Thus, the infusion of sodium acetate increases the strong ion difference by causing a net increase in cations, as the acetate anion is metabolized out of the system.…”
Section: Pharmacology Of Sodium Acetatementioning
confidence: 99%