We examine the production control of homogenous transfer lines with machines that are prone to failure, and consider inventory and backlog costs. Because problem complexity grows with line size, we developed a heuristic method based on the profile of the distribution of buffer capacities in moderate size lines in order to enable the optimization of long lines. A method consisting of analytical formalism, combined discrete/continuous simulation modelling, design of experiments (DOE), and response surface methodology (RSM) was used to optimize a set of transfer lines, with one parameter per machine, for up to 7 machines. We observed a profile in the parameter distribution which can be modeled using 4 parameters. Consequently, the optimization problem was reduced to 4 parameters, in turn greatly reducing the required optimization effort. An example of a 20-machine line, optimized at 130 runs, versus 5,243,090 runs that would be necessary to solve the 20-parameter problem, is presented to illustrate the usefulness of the parameterized profile.