Production of [17F]CH3F (), an improved PET tracer for rCBF measurement

Barnhart, Todd E.; Converse, Alexander K.; Dabbs, Kevin; Schueller, Michael; Stone, Charles K.; Nickles, Robert J.; Roberts, Andrew

doi:10.1016/j.apradiso.2004.08.044

Cited by 2 publications

(2 citation statements)

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“…The factors that affect the efficiency of 18 F production from > 18 O]water have been discussed 20 and a new design reported 21 for the water target; an electrostatic tandem accelerator has also been used 22 to make 18 F. For various applications where repeat studies are needed and where radiation dose to patients may be excessive, production of 65 second half-life 17 F has been studied. 23 Two routes, 23 [ 20 Ne(p 11Mev ,a) 17 F] and [ 16 O(d 6Mev ,n) 17 F] have been investigated. The irradiation of magnesium-24 with 12 MeV deutrons gives a good yield 24 of the positron emitter sodium-22, and the bombardment of a natural titanium target with either 13 MeV 25 or 21 MeV 26 deutrons gives an excellent yield of vanadium-48, (traces of scandium-46 are easily removed 25 by ion-exchange chromatography).…”

Section: Radionuclide Productionmentioning

confidence: 99%

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Radiochemistry and radiopharmaceuticals

Urch

Welch

2006

Annu. Rep. Prog. Chem., Sect. A: Inorg. Chem.

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Following last year's precedent this section of Annual Reports will review not only recent progress in radiochemistry, including isotope production and environmental aspects, but also in the production of radiopharmaceuticals and their use in nuclear medicine for imaging. Radiation chemistry (unless related to the stability of labelled molecules), the use of nuclear activation analysis and the inorganic chemistry of elements that are by their nature, radioactive are all excluded. HighlightsThe IAEA published 1 the results of a wide ranging review of nuclear measurements. Conferences held during 2005 which covered progress in radiochemistry, included the '4th all Polish Conference on Radiochemistry and Nuclear Chemistry' 2 and the '7th Nuclear and Radiochemistry Symposium' 3 whilst a more focused meeting dealt with the production and application of labelled compounds 4 in the oil industry. A couple of very interesting articles appeared during 2005 questioning what exactly is meant by many fundamental 'radiochemical' concepts 5 such as 'specific activity' and 'carrier-free' and indeed how the specific activities 6 of 'no-carrier-added' materials can be determined. The Proceedings of the 16th Symposium on Radiopharmaceutical Chemistry 7 covers advances made in radiopharmaceutical development and applications while the Proceedings of the Society of Nuclear Medicine 8 and the European Society of Nuclear Medicine 9 cover both radiopharmaceutical development and the application in diagnosis and therapy. A critical review has been published 10 on the application of positron emitting nuclides for use as radiopharmaceuticals.

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Section: Radionuclide Productionmentioning

confidence: 99%

“…The preparation 23 of methyl fluoride labelled with the 65 second half-life fluorine-17, has been described. The majority of development in radiolabeling molecules with fluorine utilizes the longer-lived nuclide fluorine-18.…”

Section: Labelling Tritium ( 3 H)mentioning

confidence: 99%