Production of 47Sc with natural vanadium targets: results of the PASTA project

Abstract

The goal of PASTA project (acronym for production with accelerator of 47 Sc for theranostic applications) is the determination of excitation functions associated to several nuclear reactions, aimed at yielding the theranostic radionuclide 47 Sc. This work reports the main results obtained by irradiating natural vanadium targets with proton beams up to 70 MeV. Particular care is also given to the co-production of 46 Sc, the only isotopic contaminant with half-life longer than 47 Sc. Experimental results are compared with theoretical studies by means of known nuclear reaction software tools that are publicly available.

Production of scandium radionuclides for theranostic applications: towards standardization of quality requirements

“…Experimental data on nat V can hence be interpreted in broad energy range as coming from a monoisotopic 51 V target and reaction cross-sections can be derived. The cross-sections of the nat V(p,x) 47 Sc nuclear reaction were measured up to 70 MeV proton beam (Jafari et al 2019;Pupillo et al 2019;Ditroi et al 2016), the low reaction yields are the disadvantage of this approach.…”

Continuing Nuclear Data Research for Production of Accelerator-Based Novel Radionuclides for Medical Use: A Mini-Review

“…From the new results, it is concluded that protons of energy up to about 80 MeV are very suitable for the production of 67 Cu not only when isotopically enriched 68 Zn is used as target material [16,33] but also if enriched 70 Zn would be the target, provided good radionuclidic purity is achieved. For production of the β − -emitter 47 Sc (for review see [4]), neither the intermediate energy reaction 48 Ti(p,2p) 47 Sc investigated earlier nor the 51 V(p,αp) 47 Sc process studied recently [34] appears to be successful because of the high level of the radionuclidic impurity 46 Sc. With regard to the conversion electron emitter 117m Sn, the production route 116 Cd(α,3n) 117m Sn was established [11].…”

Production of high purity 52gMn from natV targets with α beams at cyclotrons

“…The nuclear reaction mechanisms relevant for radionuclide production at cyclotrons are dominated by compound nucleus formation and by pre-equilibrium emission and all the three codes are based on nuclear reaction models developed to describe these processes. A quick review of all the models used can be found in [22] and in the codes references.…”