Production of a new tetracyclic triterpene sulfate metabolite sambacide by solid-state cultivated Fusarium sambucinum B10.2 using potato as substrate

Dong, Jian-Wei; Cai, Le; Li, Xuejiao; Duan, Rong-Ting; Shu, Yan; Chen, Feng-Yun; Wang, Jiapeng; Zhou, Hao; Ding, Zhong‐Tao

doi:10.1016/j.biortech.2016.07.014

Cited by 24 publications

(8 citation statements)

References 20 publications

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“…Strain D39 was initially cultivated by SSF on rice medium, as it was reported that SSF is an efficient fermentation process in terms of producing complex metabolites due to its longer metabolic circle. In addition, SSF offers potential benefits for microbial cultivation for bioprocesses and product development (Dong et al, 2016). However, many fatty acids and other components from the solid culture medium could be mixed with those from the fungus during the extraction process, which can significantly affect the bioassays and chemical fingerprint assays.…”

Section: Resultsmentioning

confidence: 99%

Bioactive 3-Decalinoyltetramic Acids Derivatives From a Marine-Derived Strain of the Fungus Fusarium equiseti D39

et al. 2019

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Two novel 3-decalinoyltetramic acid (3DTA) derivatives, namely fusarisetins C and D ( 1 and 2 ), and four known derivatives ( 3–6 ) were isolated from the marine-derived fungus Fusarium equiseti D39. Their structures were determined by spectroscopic data, vibrational circular dichroism (VCD) calculations, and X-ray crystallography. Compound 2 was identified as the first fusarisetin to possess an unprecedented carbon skeleton with a tetracyclic ring system comprised of a decalin moiety (6/6) and a tetramic acid moiety. A plausible biosynthetic pathway for the isolated compounds was proposed. All 3DTAs derivatives exhibited a potent phytotoxicity, and 5 also displayed a remarkable anti-phytopathogenic activity superior to the positive control resulting in damage of the cell membrane of Pseudomonas syringae and ensuing leakage of the intracellular components. Here, the phytotoxicity of fusarisetins has been reported for the first time. The OSMAC fermentation optimization approach to give 5 was performed by varying the culture media and salinities. The results showed that potato liquid medium with 1% salinity is the most favorable condition for the production of 5 .

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Section: Resultsmentioning

confidence: 99%

Bioactive 3-Decalinoyltetramic Acids Derivatives From a Marine-Derived Strain of the Fungus Fusarium equiseti D39

et al. 2019

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“…Fusarium species are distributed worldwide, and mainly attack grain crops causing quality and yield reductions; they also produce a variety of mycotoxins, such as corn gibberelenone [ 11 ], beauvericin [ 32 ], fusaproliferin [ 33 ], and fumonisin [ 34 ]. In addition, abundant active secondary metabolites have also been isolated from Fusarium sp., including antibacterial and anticancer naphthoquinone derivatives [ 35 , 36 ], anticancer and anti-inflammatory alkaloids [ 37 , 38 ], antibacterial terpenoids [ 39 ], antifungal and anti-malarial cyclodepsipeptide [ 40 ], etc. For example, F. solani has the ability to produce cyclooxygenase-2 (COX-2) inhibitor fusopoltide A [ 41 ] and anti-tumor naphthoquinone compound solaninaphthoquione [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum

Zhu

Yuan

et al. 2021

Synthetic and Systems Biotechnology

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Phytopathogenic fungi have attracted great attention as a promising source for new drug discovery. In the progress of our ongoing study for bioactive natural products from an in-house phytopathogenic fungi library, a pathogenic fungus, Fusarium proliferatum strain 13294 (FP13294), was selected for chemical investigation. Two novel aliphatic unsaturated alcohols named fusariumnols A and B ( 1 and 2 ), together with one previously characterized sesquiterpenoid lignoren ( 3 ) were identified. Structures of 1 – 3 were assigned by mass spectrometry and NMR spectroscopy. Their bioactivities were assessed against Staphylococcus epidermidis , S. aureus , and Methicillin-resistant S. aureus (MRSA). Compounds 1 and 2 exhibited weak antibacterial activity against S. epidermidis (MIC = 100 μM).

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“…Kaaniche et al [2] additionally analysed structures of obtained bioactive compounds and they proved that four most potent antimicrobials produced by Streptomyces cavourensis TN638 were macrotetrolides. Similar approach was applied to identify antimicrobial compounds produced by Fusarium sambucinum B10.2 and proved it was sambacide [10]. When surfactants produced by various Bacillus strains were tested for antimicrobial properties, researchers additionally tested their properties like emulsification activities [4] or tensioactive activity [5].…”

Section: Main Properties Of Substances Obtained From Ssf 21 Antimicrmentioning

confidence: 99%

“…The majority of identified antimicrobial compounds demonstrated activity equal to [2,13,17] or greater [10,13,15,16] than well-known antibiotics. In some cases authors did not provide results for control samples so it was not possible to assess how those substances were effective, however, inhibition zones in diffusion disk method were very prominent [4,9,14,15].…”

Section: Main Properties Of Substances Obtained From Ssf 21 Antimicrmentioning

confidence: 99%

“…Another significant group of bioactive compounds which concentration was increased by SSF was terpenes ( Table 1) and those processes were carried out by various fungi: Fusarium sambucinum B10 [10], Penicillium expansum KACC 40815 [70], Diaporthe sp. KY113119 [25], Antrodia camphorata [30], Saccharomyces cerevisiae AXAZ-1 and Kluveromyces marxianus IMB3 [27], Trichoderma viride EMCC-107 [28], and Aspergillus niger van Tieghem [29].…”

Section: Fungimentioning

confidence: 99%

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The Application of Solid State Fermentation for Obtaining Substances Useful in Healthcare

Wajda¹,

Januszek²

2021

Biotechnological Applications of Biomass

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In the current review we summarised the research involving solid state fermentation (SSF) for the production of compounds that could be used in healthcare (terpenoids, polyphenols, fibrinolytic enzymes, mycophenolic acid and others). We described several groups of obtained agents which hold various activity: antimicrobial, anti-inflammatory, immunosuppressive, anticoagulant and others (e.g. anticancer or anti-diabetic). It seems that especially terpenoids and polyphenols could be useful in that field, however, other substances such as enzymes and fatty acids play important role as well. We described main groups of microorganisms that are applied in SSF of those compounds, particularly Bacillus genus and fungi, and where possible provided information regarding genes involved in those processes. We also compared various approaches toward optimisation of SSF.

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Production of a new tetracyclic triterpene sulfate metabolite sambacide by solid-state cultivated Fusarium sambucinum B10.2 using potato as substrate

Cited by 24 publications

References 20 publications

Bioactive 3-Decalinoyltetramic Acids Derivatives From a Marine-Derived Strain of the Fungus Fusarium equiseti D39

Bioactive 3-Decalinoyltetramic Acids Derivatives From a Marine-Derived Strain of the Fungus Fusarium equiseti D39

Two novel aliphatic unsaturated alcohols isolated from a pathogenic fungus Fusarium proliferatum

The Application of Solid State Fermentation for Obtaining Substances Useful in Healthcare

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