Production of a phage-displayed single chain variable fragment antibody against infectious bursal disease virus

Pashaki, Amir Shabdini; Safarnejad, Mohammad Reza; Safdar, Amir Hossein Asgari; Safarpour, Hosein; Tabatabaie, Meisam

doi:10.4314/tjpr.v16i12.3

Cited by 3 publications

(1 citation statement)

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“…By using phage display, methods have been developed to generate specific single-chain variable fragments (scFvs) against dengue fever virus [ 203 ] and infectious bursal disease virus (IBDV) [ 204 ]. The prepared miniantibodies were used in ELISA to detect viruses in the sera of infected people.…”

Section: Phage Antibodies For Virus Detection/identificationmentioning

confidence: 99%

Antibody Phage Display Technology for Sensor-Based Virus Detection: Current Status and Future Prospects

et al. 2023

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Viruses are widespread in the environment, and many of them are major pathogens of serious plant, animal, and human diseases. The risk of pathogenicity, together with the capacity for constant mutation, emphasizes the need for measures to rapidly detect viruses. The need for highly sensitive bioanalytical methods to diagnose and monitor socially significant viral diseases has increased in the past few years. This is due, on the one hand, to the increased incidence of viral diseases in general (including the unprecedented spread of a new coronavirus infection, SARS-CoV-2), and, on the other hand, to the need to overcome the limitations of modern biomedical diagnostic methods. Phage display technology antibodies as nano-bio-engineered macromolecules can be used for sensor-based virus detection. This review analyzes the commonly used virus detection methods and approaches and shows the prospects for the use of antibodies prepared by phage display technology as sensing elements for sensor-based virus detection.

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Section: Phage Antibodies For Virus Detection/identificationmentioning

confidence: 99%