Production of a phosphatidylglycerol-like substance by genital flora bacteria

Pastorek, Joseph G.; Letellier, Rita L.; Gebbia, Kathleen

doi:10.1016/0002-9378(88)90521-2

Cited by 12 publications

(2 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another case, occurred in a diabetic mother, and in the remaining case, no explanation was apparent. These last two false negatives may have been secondary to contamination of the vulval pad with PhG from bacteria originating in the genital tract [20,24]. Nevertheless, it is worth stating that the sensitivity of the method we describe in the total population of infants is similar to, and not lower than that found by other authors who used amniotic fluid obtained transabdominally employing a sterile technique (table VII).…”

Section: Discussionmentioning

confidence: 43%

Phosphatidylglycerol determination in the amniotic fluid from a PAD placed over the vulva: a method for diagnosis of fetal lung maturity in cases of premature ruptured membranes

Estol

Poseiro²,

Schwarcz³

1992

Jpme

View full text Add to dashboard Cite

Four hundred and forty seven pregnant women with ruptured membranes, were prospectively studied in order to assess the diagnostic capacity of Phosphatidylglycerol (PhG) determination in amniotic fluid recovered from vulval pads in the diagnosis of Hyaline Membrane Disease (HMD). The identification of PhG was performed using one dimensional silica gel thin layer chromatography. The sensitivity of PhG determination in the diagnosis of HMD in newborns of the total population was found to be 88.2%, with a specificity of 76.9%. In the study population, the incidence of HMD was 7.6%, the negative predictive value was 98.8% and, the positive predictive value was 24.0%. When the 265 newborns of the gestational age group of less than or equal to 34 weeks is considered, we observed an incidence of HMD of 12.1%. The diagnostic capacity of PhG in this group was shown by a sensitivity of 87.5%, a specificity of 76.4%, a positive predictive value of 33.7% and a negative predictive value of 97.8%. This method of assessment of fetal lung maturity has a diagnostic capability similar to that described by other authors, who used amniotic fluid obtained vaginally or transabdominally. The procedure described here of amniotic fluid collection is non-invasive, harmless to the mother and fetus and simple to perform. The characteristics of this method, allow serial studies of the amniotic fluid to be carried out.

show abstract

Section: Discussionmentioning

confidence: 43%

Phosphatidylglycerol determination in the amniotic fluid from a PAD placed over the vulva: a method for diagnosis of fetal lung maturity in cases of premature ruptured membranes

Estol

Poseiro²,

Schwarcz³

1992

Jpme

View full text Add to dashboard Cite

show abstract

“…A key part of this was to determine its concentration and origin. This has not always been clear; some measurements proved misleading because PG from bacteria in the vagina had contaminated the samples of amniotic fluid [46,47]. Profiling of the fatty acid residues (FARs) of the PG offers a possible solution to this; FAs containing cyclopropyl or c-11 olefins indicate Escherichia coli, rather than any mammalian cell, as the source [48].…”

Section: Lung Surfactantmentioning

confidence: 99%

Is phosphatidylglycerol essential for terrestrial life?

Furse

2016

J Chem Biol

View full text Add to dashboard Cite

Lipids are of increasing importance in understanding biological systems. Lipids carrying an anionic charge are noted in particular for their electrostatic interactions with both proteins and divalent cations. However, the biological, analytical, chemical and biophysical data of such species are rarely considered together, limiting our ability to assess the true role of such lipids in vivo. In this review, evidence from a range of studies about the lipid phosphatidylglycerol is considered. This evidence supports the conclusions that this lipid is ubiquitous in living systems and generally of low abundance but probably fundamental for terrestrial life. Possible reasons for this are discussed and further questions posed.

show abstract

Markers of Fetal Lung Maturity

Ashwood¹

2004

Handbook of Clinical Laboratory Testing During Pregnancy

View full text Add to dashboard Cite

Production of a phosphatidylglycerol-like substance by genital flora bacteria

Cited by 12 publications

References 12 publications

Phosphatidylglycerol determination in the amniotic fluid from a PAD placed over the vulva: a method for diagnosis of fetal lung maturity in cases of premature ruptured membranes

Phosphatidylglycerol determination in the amniotic fluid from a PAD placed over the vulva: a method for diagnosis of fetal lung maturity in cases of premature ruptured membranes

Is phosphatidylglycerol essential for terrestrial life?

Markers of Fetal Lung Maturity

Contact Info

Product

Resources

About