Production of a Ribosome-Displayed Mouse scFv Antibody Against CD133, Analysis of Its Molecular Docking, and Molecular Dynamic Simulations of Their Interactions

Ghani, Sepideh; Bandehpour, Mojgan; Yarian, Fatemeh; Baghaei, Kaveh; Kazemi, Bahram

doi:10.1007/s12010-023-04609-4

Cited by 4 publications

(1 citation statement)

References 62 publications

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“…Combined with kinetic simulations, the binding and dissociation processes of drugs with respect to target proteins can be studied to further understand the mechanisms of drug action. Finally, the computational results can be used to guide experimental design to verify the accuracy of the computational model and further validate the drug release mechanism of SDT for tumor treatment [25]. Through the combined application of these computational methods, the drug release mechanism of SDT for tumor treatment can be understood in depth, providing theoretical guidance and prediction for drug design and the optimization of therapeutic regimens.…”

Section: Mechanisms Of Sdt For the Treatment Of Tumorsmentioning

confidence: 99%

Application of Nanomaterial-Based Sonodynamic Therapy in Tumor Therapy

Yang,

Li,

et al. 2024

Pharmaceutics

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Sonodynamic therapy (SDT) has attracted significant attention in recent years as it is an innovative approach to tumor treatment. It involves the utilization of sound waves or ultrasound (US) to activate acoustic sensitizers, enabling targeted drug release for precise tumor treatment. This review aims to provide a comprehensive overview of SDT, encompassing its underlying principles and therapeutic mechanisms, the applications of nanomaterials, and potential synergies with combination therapies. The review begins by introducing the fundamental principle of SDT and delving into the intricate mechanisms through which it facilitates tumor treatment. A detailed analysis is presented, outlining how SDT effectively destroys tumor cells by modulating drug release mechanisms. Subsequently, this review explores the diverse range of nanomaterials utilized in SDT applications and highlights their specific contributions to enhancing treatment outcomes. Furthermore, the potential to combine SDT with other therapeutic modalities such as photothermal therapy (PTT) and chemotherapy is discussed. These combined approaches aim to synergistically improve therapeutic efficacy while mitigating side effects. In conclusion, SDT emerges as a promising frontier in tumor treatment that offers personalized and effective treatment options with the potential to revolutionize patient care. As research progresses, SDT is poised to play a pivotal role in shaping the future landscape of oncology by providing patients with a broader spectrum of efficacious and tailored treatment options.

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Section: Mechanisms Of Sdt For the Treatment Of Tumorsmentioning

confidence: 99%

Application of Nanomaterial-Based Sonodynamic Therapy in Tumor Therapy

Yang,

Li,

et al. 2024

Pharmaceutics

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Modified heated CGMD simulations for discovering stable docked conformations of BiTE antibody against CD3 and CD117/c-kit

Abdul Kadir,

Che Nordin,

Shuid

et al. 2024

Molecular Simulation

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Eukaryotic ribosome display for antibody discovery: A review

Chance,

Kang

2024

HAB

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Monoclonal antibody biologics have significantly transformed the therapeutic landscape within the biopharmaceutical industry, partly due to the utilisation of discovery technologies such as the hybridoma method and phage display. While these established platforms have streamlined the development process to date, their reliance on cell transformation for antibody identification faces limitations related to library diversification and the constraints of host cell physiology. Cell-free systems like ribosome display offer a complementary approach, enabling antibody selection in a completely in vitro setting while harnessing enriched cellular molecular machinery. This review aims to provide an overview of the fundamental principles underlying the ribosome display method and its potential for advancing antibody discovery and development.

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Production of a Ribosome-Displayed Mouse scFv Antibody Against CD133, Analysis of Its Molecular Docking, and Molecular Dynamic Simulations of Their Interactions

Cited by 4 publications

References 62 publications

Application of Nanomaterial-Based Sonodynamic Therapy in Tumor Therapy

Application of Nanomaterial-Based Sonodynamic Therapy in Tumor Therapy

Modified heated CGMD simulations for discovering stable docked conformations of BiTE antibody against CD3 and CD117/c-kit

Eukaryotic ribosome display for antibody discovery: A review

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