Production of allergen-specific immunotherapeutic agents for the treatment of food allergy

Larsen, Jeppe Madura; Bang-Berthelsen, Claus Heiner; Qvortrup, Katrine; Sancho, Ana I.; Hansen, Anders Højgaard; Andersen, Kasper Ivert Hentzer; Thacker, Sonnich Sunil Nørtoft; Eiwegger, Thomas; Upton, Julia; Bøgh, Katrine Lindholm

doi:10.1080/07388551.2020.1772194

Cited by 12 publications

(7 citation statements)

References 159 publications

(246 reference statements)

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“…[16] Furthermore, Dongying relatively high humidity levels create an ideal environment for the proliferation of dust mites. [17] These microscopic organisms are a primary source of indoor allergens and thrive in humid conditions. Their presence is a significant factor in triggering allergic reactions such as allergic rhinitis, asthma, and skin-related symptoms in individuals who are sensitive to these allergens.…”

Section: Discussionmentioning

confidence: 99%

Allergen sensitization study in Dongying, China: An epidemiological study

Zhang,

Shang,

Tian

et al. 2024

Medicine

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Background: To explore the relationship between specific immunoglobulin E levels in response to prevalent pollen and food allergens among patients suffering from localized allergic diseases in the Dongying area of China, and to analyze the interconnectivity among these factors. Methods: This research encompassed allergic patients who visited the Allergy Department of Shengli Oilfield Central Hospital from January 2022 to January 2023. We examined the specific immunoglobulin E levels in the blood of 230 patients utilizing the Fobock platform provided by Jiangsu Haoeubo Company. Statistical analysis was conducted with SPSS 25.0 statistical software. The chi-square test evaluated the relevance of differences in gender and age. A value of P < .05 was considered statistically significant. Results: In this study, eggs emerged as the allergen with the highest number of sensitized individuals, closely followed by dust mite. Conversely, the least sensitized allergen was the cypress tree, closely followed by mango. Notably, male patients exhibited higher sensitivities to cottonwood (P < .05) and egg (P < .001) compared to female patients. Children aged 0 to 10 years showed increased sensitivity to variety of allergens. A significant correlation was observed among different allergens. The top ten allergen pairs with the highest correlation included Birch Tree and Cottonwood (0.88, P < .001), Cottonwood and Pine Tree (0.86, P < .001), Birch Tree and Pine Tree (0.84, P < .001), Pine Tree and Paulownia (0.81, P < .001), Dust Mite and House Dust Mite (0.76, P < .001), Birch Tree and Paulownia (0.73, P < .001), Cashew and Pistachio (0.71, P < .001), Apple and Hazelnut (0.71, P < .001), Cottonwood and Paulownia (0.71, P < .001), and Pine Tree and Ordinary Ragweed (0.70, P < .001). Conclusion: This research sheds light on the patterns of allergen sensitization in Dongying, Shandong, highlighting that egg is the most prevalent sensitizing allergen. A notably high correlation was observed between Birch Tree and Cottonwood. This study enhanced the understanding of allergic diseases, explored the causes and mechanisms of allergies, strengthened the management of allergic diseases. Furthermore, it offers valuable insights for the clinical diagnosis and prevention of allergic diseases.

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Section: Discussionmentioning

confidence: 99%

Allergen sensitization study in Dongying, China: An epidemiological study

Zhang,

Shang,

Tian

et al. 2024

Medicine

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“…The use of unprocessed allergic foods or extracted allergens in OIT is hindered by their inherent allergenicity, which can lead to anaphylaxis and contribute to the high rate of clinical adverse reactions, including angioedema, diarrhea, and urticaria [ 18 ]. Consequently, there is a pressing need for safer OIT products and the exploration of alternative patient groups and food allergens [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…In this study, we conducted a comprehensive literature search to identify eligible studies for a systematic review and a further quantified meta-analysis, aiming to clarify the ambiguous correlations between slightly processed allergen/meat from fish and crustacea and their OT potential. The relationship between processing methods and food allergenicity is a topic of ongoing controversy, and there is a significant gap between allergenicity and OT potential [ 19 ]. Our meta-analyses aimed to include all published studies that compared the intervention efficacies of different processing methods.…”

Section: Introductionmentioning

confidence: 99%

Intervention Efficacy of Slightly Processed Allergen/Meat in Oral Immunotherapy for Seafood Allergy: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis in Mouse Models and Clinical Patients

Han,

Wang,

Chen

et al. 2024

Nutrients

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Background: Seafood allergy is a significant global health concern that greatly impacts a patient’s quality of life. The intervention efficacy of oral immunotherapy (OIT), an emerging intervention strategy, for seafood allergy remains controversial. This study aimed to perform a systematic review and meta-analysis to evaluate the efficacy of slightly processed allergen/meat from fish and crustacea in OIT, both in mouse models and clinical patients. Methods: A comprehensive literature search was performed in four mainstream databases and the EBSCOhost database to identify all relevant case–control and cohort studies. The aim was to elucidate the intervention efficacy, encompassing various processing methods and assessing the efficacy of multiple major allergens in OIT. Results: The meta-analysis included five case–control studies on crustacean allergens in mouse models and 11 cohort studies on meat from fish and crustacea in clinical patients for final quantitative assessments. In mouse models, crustacean allergen substantially decreased the anaphylactic score after OIT treatment (mean difference (MD) = −1.30, p < 0.01). Subgroup analyses with low-level heterogeneities provided more reliable results for crab species (MD = −0.63, p < 0.01, I2 = 0), arginine kinase allergen (MD = −0.83, p < 0.01, I2 = 0), and Maillard reaction processing method (MD = −0.65, p < 0.01, I2 = 29%), respectively. In clinical patients, the main meta-analysis showed that the slightly processed meat significantly increased the incidence rate of oral tolerance (OT, incidence rate ratio (IRR) = 2.90, p < 0.01). Subgroup analyses for fish meat (IRR = 2.79, p < 0.01) and a simple cooking treatment (IRR = 2.36, p = 0.01) also demonstrated a substantial increase in the incidence rate of OT. Sensitivity and meta-regression analyses successfully identified specific studies contributing to heterogeneity in mouse models and clinical patients, although these studies did not impact the overall significant pooled effects. Conclusions: This meta-analysis provides preliminary evidence for the high intervention efficacy of slightly processed allergen/meat from fish and crustacea in OIT, both in mouse models and clinical patients. The Maillard reaction and cooking processing methods may emerge as potentially effective approaches to treating allergen/meat in OIT for clinical patients, offering a promising and specific treatment strategy for seafood allergy. However, these findings should be interpreted cautiously, and further supporting evidence is necessary.

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“…Watermelon seeds usually contain up to 37% oil, which is not inferior to olive oil in terms of taste (Donchenko et al, 2020). Watermelons are used for the production of artificial honey, molasses, various confectionery products and jam (Larsen et al, 2020). Watermelon seeds are used to produce oil, which is used for technical and food premises.…”

Section: Introductionmentioning

confidence: 99%

Mechanisation of the primary processing of watermelons without destroying the rind

et al. 2023

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In the countries of the Commonwealth of Independent States (CIS), the sown area of watermelon in recent years does not exceed 85 thousand hectares, although in the early 90s it was almost 132 thousand hectares, 2/3 of these areas are located in the southern regions. One of the key problems of industrial cucurbit crops production is the transition of production from largescale agricultural enterprises to small-scale private farms, the share of which today is more than 90%. At the same time, the transfer of production to the private sector provides additional profits for small producers and can be almost the only source of their income. The scientific originality of the paper is determined by the fact that the current situation indicates that the private farms have turned out to be more adapted to the specifics of market relations. Without considerable capital investments, using production technologies that are less dependent on the rise in the price of energy carriers and other material and technical resources, agricultural producers increase the output volume. The transition to the cultivation of cucurbit crops in households and small farms led to an increase in the separation of the real manufacturer from scientific achievements, the latest technologies, high-quality seeds, significantly limited the opportunities for the development of this industry.

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Production of allergen-specific immunotherapeutic agents for the treatment of food allergy

Cited by 12 publications

References 159 publications

Allergen sensitization study in Dongying, China: An epidemiological study

Allergen sensitization study in Dongying, China: An epidemiological study

Intervention Efficacy of Slightly Processed Allergen/Meat in Oral Immunotherapy for Seafood Allergy: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis in Mouse Models and Clinical Patients

Mechanisation of the primary processing of watermelons without destroying the rind

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